Overview

Agent-first workspace for failure claims, preprint watch, and biomedical evidence search.

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Compass: Clinical Trial Navigator

Free clinical trial navigator for clinics. Paste a patient profile to get matched open trials, logistics, and failure context.

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Failure Claims

Indexed failure dossiers with primary-source backing. Click a row for the full claim card.

	Title		Target		Trial	Phase	Failure
Oct 10, 2026	Ataluren and the subgroup that did not travel: a 15-year extension closes without an efficacy endpoint	Ataluren	DMD	PTC Therapeutics	NCT01247207	Phase 3	Sponsor	MRS 32	Other
Oct 10, 2026	Eniluracil, 24 years later: a target validated for drug handling, retested for disease biology	PCS6422 (eniluracil) plus capecitabine	DPYD	Processa Pharmaceuticals	NCT06568692	Phase 2	Sponsor	MRS 34	Oncology
Oct 4, 2026	Casdozokitug in hepatocellular carcinoma: a randomized phase that was designed, funded and never run	Casdozokitug	IL27	Coherus Oncology, Inc.	NCT05359861	Phase 2	Sponsor	MRS 31	Oncology
Oct 4, 2026	SAR444881 and the 2-of-6 problem: an anti-ILT2 antibody that never beat its own confidence interval	SAR444881	LILRB1	Sanofi	NCT04717375	Phase 1/2	Efficacy	MRS 35	Oncology
Oct 3, 2026	Strong genetics, weak endpoint: the OX40L asthma programme ends with RIVER-ASTHMA	Amlitelimab	TNFSF4	Sanofi	NCT06033833	Phase 2	Sponsor	MRS 36	Other
Oct 3, 2026	Who was allowed in: KEYNOTE-630 and adjuvant PD-1 blockade in cutaneous squamous cell carcinoma	Pembrolizumab	PDCD1	Merck Sharp & Dohme LLC	NCT03833167	Phase 3	Efficacy	MRS 83	Oncology
Oct 2, 2026	Positive and discontinued: forimtamig, GPRC5D and the cost of being second	Forimtamig plus carfilzomib	GPRC5D	Hoffmann-La Roche	NCT06055075	Phase 1/2	Sponsor	MRS 22	Oncology
Oct 2, 2026	Twice at scale: KEYNOTE-991 and PD-1 blockade in hormone-sensitive prostate cancer	Pembrolizumab plus enzalutamide and androgen deprivation therapy	PDCD1	Merck Sharp & Dohme LLC	NCT04191096	Phase 3	Efficacy	MRS 79	Oncology

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Preprint Watch

Latest bioRxiv preprints flagged against the clinical failure record. Click a row for the full preprint card.

	Title		Disease			DOI
Oct 10, 2026	Perturbation of the replication stress-ATR axis accelerates human erythroid differentiation but blocks terminal maturation	ATR	Chemotherapy-associated anemia (erythroid maturation failure)	1 prior	Mild	10.64898/2026.10.07.754672
Oct 10, 2026	Direct visualization of lysosome-mediated intracellular transport and membrane anchoring of TNF-α in human T cells	TNF	Chronic inflammation (TNF-alpha secretion control)	1 prior	Moderate	10.64898/2026.10.07.757379
Oct 10, 2026	PIK-75 suppresses an SREBP-centred sterol programme in PIK3CA-altered small-cell lung cancer cells, but attribution to p110α remains unresolved	PIK3CA	Small-cell lung cancer (PIK3CA-altered)	2 prior	Moderate	10.64898/2026.10.08.757520
Oct 10, 2026	Cancer-associated mutations reconfigure dynamical responses in EGFR kinase	EGFR	Non-small cell lung cancer (EGFR L858R and L858R/T790M)	3 prior	Strong	10.64898/2026.10.08.757680
Oct 10, 2026	Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scales	EGFR	Solid tumour signalling (matrix stiffness dependent EGFR activation)	3 prior	Strong	10.64898/2026.10.06.757133
Oct 10, 2026	A mitotic restriction point for extrachromosomal DNA hubs in cancer cells	WEE1	Extrachromosomal DNA-positive cancers	1 prior	Mild	10.64898/2026.10.08.757707
Oct 4, 2026	Genome-wide mapping of endogenous topoisomerase cleavage complexes reveals TOP1 at the interface of DNA topological regulation and genome instability	TOP1	Genome instability and DNA topological regulation (no specific disease indication)	1 prior	Moderate	10.64898/2026.09.30.755763
Oct 4, 2026	Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activation	TOP1	Transcriptional regulation and gene expression noise (no specific disease indication)	1 prior	Moderate	10.64898/2026.09.30.755832

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