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Preprint Watch

Daily automated cross-reference of new bioRxiv preprints against the indexed clinical failure record.

Strong contradictions

14

3+ failures or Phase 3 efficacy failure

Moderate contradictions

100

2 failures or single Phase 3 failure

Mild contradictions

59

1 failure (Phase 1 or 2)

173 flags indexed
PreprintDiseaseDOI
Oct 10, 2026Perturbation of the replication stress-ATR axis accelerates human erythroid differentiation but blocks terminal maturationJauregui-Lozano, J.; Kremer, A.; Prummel, K. D.; Zaugg, J. B.ATRChemotherapy-associated anemia (erythroid maturation failure)10.64898/2026.10.07.7546721Mild
Oct 10, 2026Direct visualization of lysosome-mediated intracellular transport and membrane anchoring of TNF-α in human T cellsBurgess, A.; Gunasekara, H.; Xie, J.; Hu, Y. S.TNFChronic inflammation (TNF-alpha secretion control)10.64898/2026.10.07.7573791Moderate
Oct 10, 2026PIK-75 suppresses an SREBP-centred sterol programme in PIK3CA-altered small-cell lung cancer cells, but attribution to p110α remains unresolvedMovaqar, A.; Yaghoubi, A.; Rezaee, S. A. R.PIK3CASmall-cell lung cancer (PIK3CA-altered)10.64898/2026.10.08.7575202Moderate
Oct 10, 2026Cancer-associated mutations reconfigure dynamical responses in EGFR kinaseTulli, L.; Lodola, A.; Mulholland, A. J.; Oliveira, A. S. F.EGFRNon-small cell lung cancer (EGFR L858R and L858R/T790M)10.64898/2026.10.08.7576803Strong
Oct 10, 2026Single molecule Grb2 dynamics reveal spatiomechanical modulation of RTK signaling across length scalesJain, K.; Thakar, D.; Parihar, K.; Lin, J. J.; Hayward, M.-K.; Musiime, M.; Lakins, J.; Hansen, S. D.; Radhakrishnan, R.; Groves, J. T.; Weaver, V. M.; Low-Nam, S. T.EGFRSolid tumour signalling (matrix stiffness dependent EGFR activation)10.64898/2026.10.06.7571333Strong
Oct 10, 2026A mitotic restriction point for extrachromosomal DNA hubs in cancer cellsYan, X.; Wong, I. T.-L.; Hassan, M. M.; Li, R.; Kraft, K.; Gnanasekar, A.; Mischel, P. S.; Chang, H. Y.WEE1Extrachromosomal DNA-positive cancers10.64898/2026.10.08.7577071Mild
Oct 4, 2026Genome-wide mapping of endogenous topoisomerase cleavage complexes reveals TOP1 at the interface of DNA topological regulation and genome instabilityLi, S.; Chen, C.TOP1Genome instability and DNA topological regulation (no specific disease indication)10.64898/2026.09.30.7557631Moderate
Oct 4, 2026Topoisomerase-mediated resolution of negative DNA supercoiling sustains human transcription and gene activationLyu, J.; Ahmed, A.; Biswas, I.; Li, S.; Chen, C.TOP1Transcriptional regulation and gene expression noise (no specific disease indication)10.64898/2026.09.30.7558321Moderate
Oct 4, 2026RasGRP1 promotes efficient intestinal tuft cell differentiationShechtman, L. A.; Depeille, P.; Smith, E.; Liang, H.-E.; Tam, T. S. Y.; Duflock, A.; Cortez, V. S.; O'Leary, C. E.; Shen, A.; Bos, W.; Fragiadakis, G. K.; combes, a. K.; Gonzalez, H.; Locksley, R. M.; Roose, J. P.EGFRIntestinal tuft cell differentiation and epithelial homeostasis10.64898/2026.09.30.7554073Strong
Oct 3, 2026Epithelial to mesenchymal transition and M2 macrophages drive aggressiveness in murine and human sarcomatoid urothelial carcinoma.Hayashi, Y.; Elias, R.; Douglass, E.; Yamamoto, A.; Schuler, M.; Feng, M.; Batourina, E. Y.; Geller, A. E.; Choi, W.; Colocho, G.; Arbuiso, A.; Jin, S.; Aragaki, A. K.; Ruland, C.; Rapiey, S.; Hoffman-Censits, J.; Kates, M.; Patel, S.; Singla, N.; Smith, A.; Russell, S.; Li, H.; Warrick, J. I.; Baraban, E.; Allenspach, K.; Mendelsohn, C. L.; Matoso, A.; Hahn, N. M.; McConkey, D. J.; Johnson, B. A.PDCD1Sarcomatoid urothelial carcinoma10.64898/2026.09.30.7557276Strong
Oct 2, 2026Double-Negative B Cell Expansion Defines a Relapse-Prone Immunophenotype in Newly Diagnosed Giant Cell ArteritisNieto-Carvalhal, B.; Monjo-Henry, I.; Campos-Fabre, C.; Garcia-Carazo, S.; Bohorquez, C.; Villalba, A.; Peiteado, D.; de Miguel, E.; Miranda-Carus, M.-E.CD19Giant cell arteritis10.64898/2026.09.25.7544365Strong
Oct 2, 2026Extracellular cGAMP transmission exacerbates neuroinflammation in aging and multiple sclerosisR. Carvalho, D.; Wang, R.; Liu, N.; Li, Y.; Younis, T.; Sclip, A.; Shin, S.; Pawluk, A.; Goodarzi, H.; Thaiss, C.; Konermann, S.; Li, L.ENPP1Multiple sclerosis and neuroinflammation of aging10.64898/2026.09.30.7547371Mild
Oct 2, 2026High-resolution measurement of ERK activation state reveals determinants of BRAF regulation and drug sensitivityAdebanjo, A. F.; Simon, J. J.; Banales Mejia, F.; Fowler, D.; Maly, D. J.BRAFBRAF-mutant cancer and RASopathy10.64898/2026.09.30.7553701Mild
Oct 2, 2026SIK3 links synaptic strength to sleep pressure through RhoA signalingKitazono, T.; Juichi, M.; Nishida, K.; Nomura, S.; Shimizu, C.; Kato, A.; Iino, Y.; Higashide, N.; Miyanishi, K.; Nakata, S.; Ageta-Ishihara, N.; Sawada, T.; Shi, S.; Funato, H.; Yanagisawa, M.SIK3Sleep homeostasis and synaptic regulation10.64898/2026.09.26.7545851Mild
Oct 1, 2026Treatment-free interval duration during T-cell engager conditioning shapes simulated T-cell exhaustion and post-transfer tumor controlObertopp, N.; Froid, M.; Pilon-Thomas, S.; Basanta, D.CD19Relapsed or refractory B-cell acute lymphoblastic leukaemia10.1101/2025.11.17.6888734Strong
Oct 1, 2026Disrupting aberrant EGFR catalytic trimers reverses T790M gefitinib resistanceRoberts, S. K.; Galdadas, I.; Piasentin, N.; Needham, S. R.; Zanetti-Domingues, L. C.; Davis, B. M.; Man, R. C. H.; Clarke, D. T.; Clayton, A. H. A.; Rolfe, D. J.; Fruhwirth, G. O.; Gervasio, F. L.; Martin-Fernandez, M. L.EGFREGFR-mutant non-small cell lung carcinoma with acquired tyrosine kinase inhibitor resistance10.64898/2026.09.24.7540953Strong
Oct 1, 2026Structural and Energetic Determinants of Monobody Recognition of Oncogenic KRAS VariantsKumar, A.; Huang, Y.-m. M.KRASOncogenic KRAS-variant solid tumours10.64898/2026.07.09.7375522Moderate
Oct 1, 2026Hyper-mutational processes provide a head-start for weak cancer drivers: explaining atypical KRAS variantsNicholson, M. D.; Tomlinson, I.KRASPOLE-mutant and mismatch repair deficient colorectal cancer10.1101/2025.01.29.6354992Moderate
Oct 1, 2026The Smac mimetic drug Xevinapant sensitizes triple negative breast cancer to radiotherapy-induced cell death in a TNFα dependent mannerFaye, M. D.; Lafontaine, J.; Wong, P.; Menard, C.TNFTriple-negative breast cancer10.64898/2026.09.29.7555581Moderate
Oct 1, 2026The Actin Cytoskeleton and Caveolae Regulate MERTK Cleavage by ADAM17.Nicholson, R. A.; Vrieze, A.; Heit, B.MERTKEfferocytosis and tumour microenvironment biology in advanced solid tumours10.64898/2026.09.29.7553451Mild
Sep 29, 2026Pathway-wide base editing charts chemical-genetic interactions in MAPK signalingWoods, J.; Hu, C. X. Y.; Jang, D. M.; Freedman, C.; Canarelli, S.; Kwok, H. S.; Iram, I.; Eck, M. J.; Liau, B.KRASMAPK pathway driven cancers10.64898/2026.09.25.7536392Moderate
Sep 29, 2026Hypothalamic Farnesoid X Receptor deficiency alters energy balance by modulating hepatic glucose production and adipose tissue metabolism through central insulin signaling.Blondel, C.; Bourouh, C.; Nicolas, E.; Vadel, A.; Dorchies, E.; Vallez, E.; Tailleux, A.; Lestavel, S.; Staels, B.; Bantubungi, K.NR1H4Energy balance, hepatic glucose production and adipose tissue metabolism (preclinical, mouse)10.64898/2026.09.21.7531412Moderate
Sep 29, 2026YAP/TAZ-controlled ERK dynamics coordinate progenitor expansion and differentiation commitmentSharma, S.; Berger, H. A.; Zhang, Z.; Meyer, T.; Teruel, M. N.PPARGAdipocyte differentiation (preclinical cell biology, no disease indication stated)10.64898/2026.09.24.7539502Moderate
Sep 29, 2026Combined Loss of VHL and TSC1 Drives Clear Cell Renal Cell Carcinoma with Metabolic and Redox Reprogramming that Creates an NRF2 DependencyXu, J.; Cheng, X.; Aboud, O. A.; Chen, Y.; Bialik, A.; Reznik, E.; Oyama, T.; Tickoo, S.; Weiss, R. H.; Cheng, E. H.; Hsieh, J. J.NFE2L2Clear cell renal cell carcinoma with combined VHL and TSC1 loss10.64898/2026.09.24.7541881Mild
Sep 28, 2026Engineering CAR-T cells to remodel the mucin-rich cancer cell glycocalyxPark, S.; Ho, C.; Wolff, A. N.; Fan, Y.; Bouffard, A. A.; Paek, J.; Mucci, A.; Berger, T. R.; Paszek, M. J.; Maus, M. V.KLK5Mucin-rich solid tumours targeted by MUC17 CAR-T cells (preclinical xenograft models)10.64898/2026.09.25.7544901Mild
Sep 27, 2026MYC-Hyperactivated Osteosarcoma Models Exhibit Resistance to Cabozantinib plus TIGIT BlockadeKappa, S. S.; Patel, T.; Nirala, B.; Kurenbekova, L.; Shuck, R.; Yustein, J. T.TIGITMYC-hyperactivated osteosarcoma10.64898/2026.09.21.7530334Strong
Sep 27, 2026Integrative analysis of the MDM2 promoter switch and cellular lineage plasticity in colorectal cancer: a contrast between the autonomous-proliferation type (CIN/CMS2) and the environment-adaptive type (MSI/gastric metaplasia)Tsukui, T.; Tsuda, K.; Yao, R.; Shin, K.MDM2Colorectal cancer10.64898/2026.09.21.7533571Mild
Sep 26, 2026Evinacumab Enables Discontinuation of LDL Apheresis in Homozygous Familial Hypercholesterolemia: A Case ReportGarcía Aguilar H, Fokine Dotsenko AGS, Vazquez-Del Campo AR, Gutiérrez–Múgica H, González M.ANGPTL3Homozygous familial hypercholesterolemia10.20944/preprints202609.1974.v11Mild
Sep 26, 2026KLK5 overexpression predicts poor prognosis and promotes migration and adhesion in non-small cell lung cancerStuardo-Parada A, Figueroa CD, Turones L, Robles CM, Bascur P, Pavicic F, Torres-Farfán C, López R, Villarroel-Espindola F, Dreyer T, Magdolen V, Ehrenfeld P.KLK5Non-small cell lung cancer10.21203/rs.3.rs-10133408/v11Mild
Sep 26, 2026A Rationally Designed Transgene Drives CAR T Functional Persistence and Durable Regression of Solid TumorsAmin RH, Haworth KG, Moffett HF, Chen JC, Park L, Yokoyama JK, Wang AL, Tait LJ, Steele MM, Crowl JT, Davenport TM, DeSautelle J, Hammer JL, Obenza WM, Montoya VR, Kirkpatrick RL, Tan T, Shirley KM, Hammerson B, Langan RA, Clausen DS, Sample PJ, Weitzner BD, Yuan S, Lajoie MJ, Boyken SE, Foster AE.MSLNMesothelin-expressing solid tumors (lung and ovarian models)10.64898/2026.09.18.7527541Mild
Sep 26, 2026Immune-Depleted Features of HER2-Expressing Gastric Cancer and Immune Remodeling After Trastuzumab-Containing TherapyHarima T, Hu Q, Ando K, Kawazoe T, Nambara S, Tsuda Y, Nakanoko T, Oki E, Yoshizumi T.ERBB2HER2-expressing gastric cancer10.21203/rs.3.rs-10922414/v12Moderate
Sep 25, 2026Gene-Based Rare Variant Burden Analyses Across Biobanks Identify Novel High-Risk Genes for Thoracic Aortic DiseaseMurdock DR, Guan P, Guo D, Bermudez F, DePaolo J, Cabot J, Nazeen S, Nasir H, Gupta R, Jha A, Elefteriades J, McGivern B, McWalter K, Anderson S, Jones C, Lynch J, Chang K, Tsao P, VA Million Veteran Program, Penn Medicine BioBank, Damrauer S, Chen H, Milewicz D.ENPP1Thoracic aortic disease (aneurysm and dissection)10.64898/2026.09.16.263632541Mild
Sep 25, 2026Catalytically inactive PARP1 protein drives PARP inhibitor induced hematological toxicityLin X, Shao Z, Yaneva D, Jiang W, Menolfi D, Bhandari SK, Lee BJ, Schmucker M, Yaneva F, Tomkinson AE, Stingele J, Zha S.PARP1PARP inhibitor associated haematological toxicity in homologous recombination deficient cancer10.64898/2026.09.21.7533122Moderate
Sep 25, 2026MMRi62 induces iron depletion-driven apoptosis through a ferritin-independent mechanismSegui F, Pagnuzzi M, Antiq J, Durivault J, Vial V, Bogliotti N, Leray I, Vucetic M, Picco V.MDM2Medulloblastoma10.64898/2026.09.22.7535151Mild
Sep 25, 2026Radiation therapy synergizes with mRNA vaccination to overcome microglia-mediated suppression of dendritic cell migration and T cell priming in glioblastomaWisdom AJ, Rogers ZJ, Chatterjee F, Cui Y, Garcia-Rivera L, Temple H, Abdelfattah NS, Coombs T, Van R, Tafuri Del Vecchio C, So HK, Heim T, Wolczanski G, Mount CW, Butty V, Levine SS, Cormier K, Love JC, Kaech SM, Jacks T, White F, Spranger S.AXLGlioblastoma10.64898/2026.09.18.7527411Mild
Sep 25, 2026Clade B serpins promote direct basal-to-goblet cell differentiation in airways of patients with chronic obstructive pulmonary diseaseTufenkjian TS, Blackburn JB, Nichols D, Vasquez A, Shaver C, Ware L, Blackwell TS, Richmond BW.IL1BChronic obstructive pulmonary disease (goblet cell hyperplasia)10.64898/2026.09.21.7532781Moderate
Sep 24, 2026Spatial transcriptomics reveals epithelial-immune remodeling preceding malignant transformation of oral premalignant lesionsJiang YJ, Ali I, Genkinger JM, King OD, Phillipone E, Momen-Heravi F.TIGITOral premalignant lesions progressing to oral squamous cell carcinoma10.64898/2026.09.17.7515974Strong
Sep 24, 2026Integrated genomic meta-analysis identifies cell-type-specific signatures and targets in early Alzheimer's diseaseSteinruecke M, Baillie JK, Jiwaji Z.APPEarly Alzheimer's disease10.64898/2026.09.21.263621501Moderate
Sep 24, 2026Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian CancerZhang S, Fu Z, Zhou Y, Metcalfe TX, Vuong TT, Brubaker LW, Bitler BG, O'Hagan HM, Nephew KP.MAT2AHigh-grade serous ovarian cancer (platinum-resistant)10.64898/2026.09.22.7535501Mild
Sep 24, 2026The Activation of the Transcription Factor NRF2 in Epithelial Cells Lining the Kidney Cysts in Tuberous Sclerosis Complex (TSC): The Interplay of Fumarate Hydratase 1, KEAP1, and NRF2 in Kidney CystogenesisBarone S, Zahedi K, Soleimani M.NFE2L2Tuberous sclerosis complex kidney cystogenesis10.64898/2026.09.22.7535361Mild
Sep 23, 2026Biomarker-Targeted O6-Guanine Alkylation Potentiates ATR Inhibitor Response in De Novo and Relapsed/Refractory AMLBhardwaj, P.; Baassiri, A.; Sundaram, R. K.; Friedman, S.; Elia, J.; VanOudenhove, J.; Heer, C.; Kiwan, A.; Matthews, M.; Gueble, S.; Halene, S.; Bindra, R.ATRAcute myeloid leukemia10.64898/2026.09.19.7512701Mild
Sep 23, 2026Dual Immunoliposome Targeting of PD-L1 and CSF1R affects T-Cell readouts in tumor-conditioned co-cultures: An In Vitro Study in Glioblastoma and MedulloblastomaAsad Pour, O.; Asadpour, A.; Ghanam, J.; Best, J.; Rahbarizadeh, F.; Hetze, S.; Chetty, V. K.; Barthel, L.; Amoozgar, Z.; Schmidt, H. H.; Thakur, B. K.CD274Glioblastoma and medulloblastoma10.64898/2026.09.16.7514172Moderate
Sep 23, 2026Proton FLASH radiotherapy enhances control of triple-negative breast cancer through STING-IRF3 and CD8+ T-cell immunityLoap, P.; Paraskevaidis, I.; Cheptea, C.; Kolker, K.; Kim, M.; Setianegara, J.; Singh, K.; Berianu, I. M.; Metz, J.; Greenberg, R. A.; Bilker, W. B.; Berlin, E.; Koumenis, C.; Assenmacher, C.-A.; Diffenderfer, E.; Taunk, N. K.; Verginadis, I. I.CD40Triple-negative breast cancer10.64898/2026.09.19.7516231Moderate
Sep 23, 2026Dual-targeted nanoparticles enable the ex vivo generation of cytotoxic and phagocytic CAR effector cellsHong, J.; Lim, J.; Park, M.; Song, J.; Lee, B. J.; Park, M.; Shin, M.-K.; Seo, H.; Kang, H. J.; Kim, B.-S.; Lee, C.-H.CD19B-cell malignancy10.64898/2026.09.21.7530743Strong
Sep 22, 2026Autonomous MTOR activation in COPD airway epithelium impairs resolution through persistent mucus cell metaplasia and lysosome dysfunctionKudrna, K., Vilches, F. L., Wang, X., Wang, J., Hugo, T., Bailey, K. L. et al.MTORChronic obstructive pulmonary disease (airway mucous cell metaplasia)10.64898/2026.09.15.7518281Moderate
Sep 22, 2026Distinct phenotypic consequences of cholangiocarcinoma-associated FGFR2 alterations depend on biliary epithelial cell stateChiasson-MacKenzie, C., Zhang, Y., O'Loughlin, E., Dave, P., Menon, A. S., Vijay, V. et al.FGFR2Intrahepatic cholangiocarcinoma10.1101/2024.08.30.6103602Moderate
Sep 22, 2026Centenarians maintain cognition by resisting amyloid-β or decoupling it from tau propagationRohde, S. K., Luimes, M. C., Rozemuller, A. J. M., Hulsman, M., van der Lee, S. J., Sikkes, S. A. M. et al.APPAlzheimer's disease (resilience in cognitively healthy centenarians)10.64898/2026.09.18.263633761Moderate
Sep 21, 2026Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS RiskZhao T, Hoffman MM, Wu G, Belzil VV.C9orf72Amyotrophic lateral sclerosis10.64898/2026.09.17.263633191Mild
Sep 20, 2026Na+/K+-ATPase Blockade Reversibly Attenuates Proliferation and Metabolic Function in K562 Human Myelogenous Leukemia CellsBowden, S. R.; Colton, E. T.; Norgaard, A. D.; Haas, M. M.; Dunnigan, E. R.; Goven, C. J.; Goven, G. O.; Hinnenkamp, T. J.; Walker, K. D.; Ballance, T. M.; Kathol, B. I.; Murphy, E. R.; Van Slyke, K. M.; Webb, R. J.; Biggane, E. R.; Biggane, J. P.ATP1A1Chronic myelogenous leukemia10.64898/2026.09.11.7510861Moderate
Sep 20, 2026State-Dependent 3D Enhancer Architecture Resolves a Shared Schizophrenia and Multiple Sclerosis Ketone and Lactate Sensing Logic GateKrantz, B. A.HCAR2Multiple sclerosis and schizophrenia10.64898/2026.06.30.7356501Mild
Sep 19, 2026Pan-B-Lineage Targeting with Adapter CAR-T Cells Controls Antigen-Heterogeneous LymphomaKrost, S.; Mast, A.-S.; Atar, D.; Kristmann, B.; Scheuermann, S.; Seitz, C. M.CD19Antigen-heterogeneous B-lineage lymphoma (Burkitt lymphoma model)10.64898/2026.09.12.7511713Strong
Sep 19, 2026ERK5 inhibition triggers CDK6 proteasomal degradation and enhances palbociclib efficacy in cancer cellsFaundez Vidiella, C.; Sfragano, Y.; Tusa, I.; Stecca, B.; Espinosa Gil, S.; Lizcano, J. M.; Rovida, E.CDK6Advanced melanoma and serous endometrial cancer10.64898/2026.09.17.7522912Moderate
Sep 19, 2026Newly identified COPD GWAS protein interactors reveal a potential disease network moduleDeritei, D.; Inuzuka, H.; Zhang, C.; Castaldi, P. J.; Asara, J. M.; Madha-Krause, S.; Moritz, R. L.; Cho, M. H.; Glass, K.; Wei, W.; Silverman, E. K.TGM2Chronic obstructive pulmonary disease10.64898/2026.09.17.7524661Moderate
Sep 19, 2026Spatial/molecular heterogeneity and treatment response in HER2+ early breast cancer: Translational analyses from the DAPHNe trialChen, E.; Schlam, I.; Shimada, K.; Li, T.; Ogayo, E. R.; Patel, A.; Davis, J.; Lin, J.-R.; Schultz, A.; Townsend, M. G.; Zheng, K. F.; Wanderley, C. W.; Pastorello, R.; New, F.; Metzger, E.; Sinclair, N.; Spring, L. M.; Faggen, M.; Constantine, M.; Desai, N.; Tung, N.; Tayob, N.; Krop, I. E.; Tolaney, S. M.; Winer, E. P.; Guerriero, J. L.; Mittendorf, E. A.; Waks, A. G.ERBB2HER2-positive early breast cancer10.64898/2026.09.17.7524072Moderate
Sep 18, 2026Cul5Wsb2 uses BCL2 proteins as co-receptors to target Bim for degradation.Vaysse-Zinkhofer, W.; Alcindor, E.; Garaffo, N.; Toczyski, D. P.BCL2Not disease-specified (apoptosis regulation); matched Claidex claims are in acute myeloid leukemia10.1101/2025.08.14.6704142Moderate
Sep 18, 2026A directed TM->JM coupling in receptor tyrosine kinase dimers, set by activating mutations and the membrane environmentSato, T.; Tamagaki-Asahina, H.EGFRNot disease-specified (receptor tyrosine kinase activation); matched Claidex claims are in EGFR mutation-positive non-small cell lung carcinoma10.64898/2026.05.22.7273182Moderate
Sep 17, 2026Simulated Annealing Identifies Five Shared Drivers of T Cell Exhaustion Across Four Human CancersEbadi, A.; Hashemi, M.TIGITNon-small cell lung carcinoma, melanoma, colorectal carcinoma and hepatocellular carcinoma10.64898/2026.09.15.263631024Strong
Sep 17, 2026CDK4 or CDK6 upregulation induces DNA replication stress and genomic instability to cause EGFR targeted therapy resistance in lung cancerGini, B.; Gui, P.; Wu, W.; Kerr, D. L.; Tan, L.; Barbosa, D.; Olivas, V.; Allegakoen, P.; Gomez, C.; Halliday, P.; Elmes, S.; Steri, V.; Chakrabarti, T.; Bivona, T. G.; Blakely, C. M.EGFREGFR mutation-positive lung adenocarcinoma10.1101/2024.03.12.5846382Moderate
Sep 17, 2026ERBB2 establishes the timing of progesterone priming required for uterine receptivityLi, B.; Zhang, C.; Dewar, A.; Liu, X.; Deng, W.; Qi, H.; Dey, S. K.; Sun, X.ERBB2Uterine receptivity and recurrent spontaneous abortion10.64898/2026.09.14.7515182Moderate
Sep 17, 2026A bispecific antibody targeting a membrane-proximal ASGPR1 region promotes TNF-α recruitment and uptakeSong, X.; Li, S.; HaShan, A.; Du, J.; Sun, Y.; Jiang, X. T.; Liu, X.TNFInflammatory disease and cytokine clearance10.64898/2026.09.11.7508481Moderate
Sep 17, 2026LNA043 and ANGPTL3 Interactions with Integrin α5β1 and Fibronectin Drive Distinct Stromal and Immune ResponsesGrosso, A.; Cucuzza, S.; Gambs, E.; Lapointe, T.; Huynh, T.; Kuzu, G.; King, F.; Ng, K.; Shi, J.; Vogel, M.; Gerwin, N.; Halleux, C.; Fornaro, M.ANGPTL3Osteoarthritis10.64898/2026.09.14.7513661Mild
Sep 16, 2026Characterization of the Grin1Q536R/+ mouse: a preclinical model for GRIN1-related neurodevelopmental disorderSullivan, M. T.; Yan, Y.; Vania, L.; Tidball, P.; Pauli, Q.; Lipina, T. V.; Venkatesan, S.; Finnie, P. B.; Fujiwara, E.; Horsfall, W.; Georgiou, J.; McCullumsmith, R. E.; Lambe, E. K.; Bonin, R. E.; Salahpour, A.; Collingridge, G. L.; Ramsey, A. J.GRIN1GRIN1-related neurodevelopmental disorder10.64898/2026.09.09.7504651Moderate
Sep 16, 2026Glucocorticoids reprogram human AML leukemic stem cells to promote elimination through differentiation and apoptosisIasenza, I. A.; Sun, Y. L.; Best, L.; Dakik, H.; Boileau, M.; Neumann, A. L.; Arreba-Tutusaus, P.; Saby, M.; Hebert, J.; Minden, M.; Cavallone, L.; Williams, C.; Jean-Claude, B.; Eppert, K.NR3C1Acute myeloid leukemia10.64898/2026.09.09.7501912Moderate
Sep 15, 2026ZNF217 promotes receptor tyrosine kinase plasticity and AXL-ERK dependency in ovarian cancerPandya MJ, Hoffman J, Padmanabhan A.ERBB2Ovarian cancer10.64898/2026.09.11.7509132Moderate
Sep 14, 2026A De Novo, Intragenic Modifier in Cis Rescues Scn8a-N1768D Epilepsy and Defines a Therapeutic Window Bounded by Gain- and Loss-of-FunctionBahramnejad, E.; Hammer, M. F.; Hiller, V. J.SCN8ASCN8A developmental and epileptic encephalopathy (DEE13)10.64898/2026.09.08.7501611Mild
Sep 12, 2026Patient-derived IgG Amplifies Fcγ Receptor-Dependent Colonic Inflammation During Immune Checkpoint BlockadeVoloshyna, I.; Patskovsky, Y.; Sandigursky, S.; Sreenivasaiah, C.; Bayrakta, E. C.; Tardio, E.; Lopez, A. V.; Idga, S.; Ng, C.; Ibrahim, M.; Goldberg, C.; Zhurova, A.; Freih, R.; Mastroianni, J.; Hao, Y.; Mishra, P.; Khodadadi-Jamayran, A.; Mehnert, J.; Silverman, G. J.; Fa'ak, F.; Osman, I.; Krogsgaard, M.PDCD1Immune checkpoint inhibitor-associated colitis in melanoma (anti-PD-1 and anti-CTLA-4 treated)10.64898/2026.06.03.7296922Moderate
Sep 10, 2026Interleukin-1 receptor antagonist is a conserved factor for exacerbating tuberculosis susceptibilityLee, O. V.; Pathak, E.; Hernandez-Bazan, S.; Ji, D. X.; Rosa, B. A.; Jaye, D. L.; Suliman, S.; Mitreva, M.; Gabay, C.; Vance, R. E.; Kotov, D. I.TNFTuberculosis (Mycobacterium tuberculosis infection)10.1101/2023.10.27.5644201Moderate
Sep 9, 2026CAMOR and specific oncogene-driven lncRNAs mediate carcinogenic functions downstream of MYC, mutant KRAS, and mutant TP53Grzes, M.; Jaiswar, A.; Kazmierczak, W.; Olesinski, T.; Nowak-Niezgoda, M.; Walerych, D.KRASColorectal, lung and pancreatic cancer (mutant KRAS driven)10.64898/2026.09.04.7493812Moderate
Sep 9, 2026The Greatwall/PP2A-B55α axis remodels the G2/M boundary and shapes cellular dependence on PKMYT1Zach, R.; Herbert, A.; Dragoi, C.-M.; Meredith, M.; Gadelkarim, L.; Foster, W.; Hochegger, H.WEE1Cancer cell G2/M control (tumour-derived cells)10.64898/2026.09.04.7494071Mild
Sep 9, 2026eIF4A inhibition disrupts resistance-associated translational and metabolic programs in BRAF-mutant melanomaSchcolnik-Cabrera, A.; Takdenti, M.; Sadr Hashemi Nejad, A.; Nouhi, Z.; St-Amand, S.; Capdevielle, C.; Issa, D.; Riaud, M.; Rose, A. A. N.; Khacho, M.; Mallette, F. A.; Roffe, M.; Alain, T.; Topisirovic, I.; Hulea, L.BRAFBRAF-mutant melanoma with acquired MAPK inhibitor resistance10.64898/2026.09.03.7492061Mild
Sep 9, 2026Therapeutic targeting of MYBPC3 mutation-specific hypertrophic cardiomyopathy guided by network modelingLuanpaisanon, P.; Pavelec, C. M.; Bradley, L. A.; Saucerman, J. J.; Wolf, M. J.MTORMYBPC3-mutant hypertrophic cardiomyopathy10.64898/2026.09.03.7491731Moderate
Sep 9, 2026Genetic predictors of clonal contraction and hematologic response in IDH mutant myeloid malignanciesSong, A.; Chen, Y.; Iyer, S.; Fernando, S.; Sudunagunta, V. S.; Stewart, E.; Deng, R.; Scoca, V.; Xu, J. J.; May, B.; Varabyeva, A.; Hsiao, S. J.; Freeman, C.; Mansukhani, M.; Lipsky, A. H.; Lamanna, N.; Rosenblat, T. L.; Kasbekar, M.; Jurcic, J. G.; Chernak, B.; Viny, A. D.IDH1IDH-mutant myeloid malignancies (AML, MDS and related)10.64898/2026.09.03.263618251Mild
Sep 8, 2026Venetoclax-based Therapy Improves Outcomes across the Evolving Biology of t(11;14) Multiple MyelomaSudalagunta, P. R.; Ionescu, F.; Canevarolo, R. R.; Silva, M. C. S.; DeAvila, D.; Meads, M. B.; Zhao, X.; Perez, A.; Drekolias, D.; Irimia, R.; Thapa, S.; Patel, P.; Baz, R.; Shain, K. H.; Silva, A. S.; Grajales-Cruz, A.BCL2t(11;14) multiple myeloma10.64898/2026.09.02.263619562Moderate
Sep 7, 2026A Transcriptionally Distinct Intermediate Activation State Precedes Langerhans Cell Migration from the EpidermisKiselev, A.; Schmitter-Sanchez, A. D.; Mishra, S.; Kim, H.; Williams, S.; Park, S.C3Epidermal Langerhans cell activation and skin wound repair10.1101/2025.05.29.6569121Mild
Sep 7, 2026Glucocorticoid rhythm disruption drives hyperinsulinaemia in mice through beta cell glucocorticoid receptor signallingWilson, J.; Arzeno, A. S.; Sharma, S.; Agas, A.; Lungstrum, J.; Teruel, M. N.NR3C1Hyperinsulinaemia and glucose homeostasis under disrupted glucocorticoid rhythm10.64898/2026.06.03.7300052Moderate
Sep 5, 2026Selective Immune Silencing by Targeted TGF-β MimicsSun, Q.; Ogishi, M.; Barrett, A. K.; Jiang, H.; Yan, H.; Sola, E.; Zhang, J.; Xiao, P.; Lyu, H.; Salehi, A.; Liu, H.; Tang, Q.; Davis, M. M.; Negrin, R. S.; Lanz, T. V.; Garcia, K. C.CD19B cell mediated autoimmunity and graft-versus-host disease10.64898/2026.01.19.7004102Moderate
Sep 5, 2026Structural basis of endogenous inverse agonism and subtype selectivity at melanocortin receptorsLiu, X.; Sun, Q.; Zhang, S.; Zhang, X.; Sun, X.MC1RMelanocortin receptor signalling, with relevance to melanoma targeting10.64898/2026.09.03.7487151Mild
Sep 5, 2026Defective synapto-nuclear signaling contributes to motoneuron vulnerability in SOD1-ALSGrycz, K.; Jan, C.; Zawistowski, P.; Wasicki, B.; Ozkan, B.; Aousji, O.; Sirtori, R.; Fallini, C.; Caron, G.; Danner, S. M.; Roselli, F.; Zytnicki, D.; Baczyk, M.SOD1Amyotrophic lateral sclerosis10.64898/2026.09.01.7485681Moderate
Sep 4, 2026Microbial valerate is associated with CAR T dysbiosis and its supplementation enhances CAR T function in B-cell lymphomaRehman, L.; Song, W.; Rehman, A.; Singh, K.; Rawat, S. G.; Darbaniyan, F.; Le, C. C.; Aletti, F. M.; Weng, J.; Liu, J.; Cheng, X.; Tang, Y.; Patchva, S.; Richard, M. D.; Chu, F.; Cao, J.; Flowers, C. R.; Shpall, E. J.; Tanner, M. R.; Fahrmann, J.; Elinav, E.; Stein-Thoeringer, C. K.; Jain, M. D.; Jenq, R. R.; Jain, A.; Neelapu, S. S.; Zheng, Y.; Saini, N. Y.CD19B-cell lymphoma (CD19 CAR T-cell therapy)10.64898/2026.09.01.7487112Moderate
Sep 3, 2026Abundant Glomerular Neutrophil Extracellular Traps in C3 GlomerulopathyO'Sullivan, K.; khandelwal, p.; Walker, P. D.; hickey, m.; Licht, C.C3C3 glomerulopathy (dense deposit disease and C3 glomerulonephritis)10.64898/2026.08.27.7473861Mild
Sep 2, 2026The circadian system is affected by Alzheimers disease independently from amyloid beta depositsCalligaro, H.; Khov, B.; Noel, K.; Glina, A.; van Rosmalen, L.; Ramasamy, R.; Li, Y.; Lam, M. T. Y.; Le, H.; Kim, K.-Y.; Ju, W.-K.; Ellisman, M.; Panda, S.APPAlzheimer's disease (circadian and sleep dysfunction)10.64898/2026.08.25.7445991Moderate
Sep 2, 2026Microsecond molecular dynamics of SOD1 variants suggest a structural basis for divergent ALS clinical outcomesRefaee, A. A.; Milanetti, E.; Roeder, K.; Ruocco, G.; Iacoangeli, A.SOD1Amyotrophic lateral sclerosis (SOD1-mutant)10.64898/2026.08.29.7479991Moderate
Sep 2, 2026Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer's diseaseZeng, J.; Abd-Elraouf, K.; Loi, G. W. Z.; Saipuljumri, E. N.; O'Connor, L. M.; Indajang, J.; Reynolds, R.; Barron, A. M.; Lo, C. H.TNFAlzheimer's disease (TNFR1-mediated neuronal necroptosis)10.1101/2023.10.12.5620411Moderate
Sep 2, 2026Dissecting the TMEM132A-EGFR Dependency to Unlock Translational Therapeutic Opportunities for Pan-Solid TumorLiu, X.; Fu, Y.; Ni, Q.; Ning, C.; Wang, J.; Wu, M.; Zhang, C.; Wang, J.; Qian, J.; Fang, W.; Zhang, D.; Li, X.; Zhao, F.; Gong, L.; Yao, J.; Song, N.; He, Y.; Wei, X.; Qin, C.; Wang, J.EGFRPan-solid tumors (EGFR-dependent signaling and EGFR-TKI resistance)10.64898/2026.08.30.7465861Mild
Sep 2, 2026Antibody-dependent priming of spontaneous germinal centers by autoreactive B cellsKim, D.; Chiang, K.; Largent, A. D.; Pitner, R. A.; Ponnan, S. M.; McKinney, B. J.; James, R. G.; Rawlings, D. J.; Jackson, S. W.CD40Systemic autoimmunity (spontaneous germinal centre formation)10.64898/2026.08.27.7453731Moderate
Sep 1, 2026Hepatic stellate cell FXR signaling regulates context-dependent functions in liver homeostasis and fibrosis.Vinod, M.; Zummo, F.-P.; Gheeraert, C.; Gouda, Z.; Courquet, S.; Dorchies, E.; Thuret, L.; Lapage, M.; Guille, L.; Bobowski-Gerard, M.; Pourpe, C.; Launay, V.; Derhoudi, M.; Bonnefond, A.; Eberle, D.; Haas, J.; Dubois-Chevalier, J.; Eeckhoute, J.; Lestavel, S.; Staels, B.; Lefebvre, P.; Berthier, A.NR1H4Liver fibrosis and chronic liver injury10.64898/2026.08.29.7475372Moderate
Sep 1, 2026Multiple mechanisms regulate the nanoscale organization of PD-L1 at the cell surfaceFranken, G. A.; Arp, A. B.; Cerina, D.; van Esch, V. M. R.; Scheijen, B.; van Spriel, A. B.CD274Solid tumours (PD-L1-mediated immune evasion)10.64898/2026.08.31.7482002Moderate
Sep 1, 2026Spatial agent-based modeling and interpretable machine learning identify determinants of combination-therapy response in HER2-heterogeneous breast cancerRahman, N.; Jackson, T. L.ERBB2HER2-heterogeneous breast cancer10.64898/2026.03.14.7117742Moderate
Sep 1, 2026Disruption of the interferon-gamma axis limits chimeric antigen receptor T cell efficacy against acute myeloid leukemiaMurren, N.; King, I.; Mahoney, L.; Roy, J.; Kletzien, O. A.; Collins, M.; Geffe, S.; Kalcheim, L.; Richards, R.IL3RAAcute myeloid leukaemia10.64898/2026.08.28.7479001Mild
Aug 31, 2026Hyperactivation of the AXL-ICD/SIRT2 axis by Amyloid-β impairs astrocytic autophagic flux and exacerbates neuroinflammationKim, T. Y.; Bhalla, M.; Park, U. P.; Hyeon, S. J.; Hwang, I.-Y.; Seo, Y.; Youn, W.; Lee, J.-A.; Lee, J.; Lee, B.; Ryu, H.; Lee, C. J.AXLAlzheimer's disease10.64898/2026.08.23.7465081Mild
Aug 31, 2026Cellular inhibitor of apoptosis protein (cIAP) is a convergent hub that couples BCR-CD40 signal dynamics to B cell fateInoue, K.; Shinohara, H.CD40Not disease-specific, primary mouse B cells10.64898/2026.08.26.7474401Moderate
Aug 31, 2026Higher T-cell density in primary prostate cancer is associated with reduced fraction of CD8 effector cells and increased TIGITAwad, S.; Calagua, C.; Voznesensky, O.; Abdelkader, S.; Mohanna, R.; Kissick, H.; Signoretti, S.; Einstein, D.; Balk, S.TIGITPrimary prostate cancer10.64898/2026.08.27.7475242Moderate
Aug 29, 2026Single-atom inhibition of oncogenic drivers through cysteine coordinationZhao, W.; Chen, Z.; Cao, K.; Huo, W.; Zhang, Y.; Chen, S.; Xia, D.; Yuan, Q.; Cao, P.; Sun, S.; Gao, X.EGFREGFR-mutant and KRAS G12C-mutant non-small cell lung cancer10.64898/2026.08.27.7474892Moderate
Aug 29, 2026Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functionsLin, Y.-c.; Seno, T.; Hsu, A. Y.; Cartier, A.; Kuo, A.; Levesque, M. V.; Ghosh, A.; Fohmann, I.; Blaho, V. A.; Galvani, S.; Crocker, R.; Kazer, S. W.; Ordovas-Montanes, J.; Luo, H. R.; Hla, T.S1PR1Neutrophil-mediated inflammation and bacterial host defence10.64898/2026.02.05.7037831Moderate
Aug 28, 2026Nuclear exclusion of menin drives functional MEN1 deficiency in non-MEN1 prolactinomas: mouse models and human biopsiesPeña-Zanoni M, Flores-Martínez Á, Bornancini D, Abeledo Machado A, Segobia V, Rulli S, Luque R, Díaz-Torga G.MEN1Prolactinoma (non-MEN1, sporadic)10.64898/2026.08.19.7457712Moderate
Aug 28, 2026Atypical MDM2 p53 Regulation and Chemosensitivity Induced by Proximal PAS DeletionKim M, Yoon C, Jun J, Lee Y, Chung H, Kim Y.MDM2Lung adenocarcinoma (A549 model), TP53 wild-type cancers10.64898/2026.08.23.7464941Mild
Aug 28, 2026Epithelial and γδ T cell CD47 have complementary yet distinct roles in regulating γδ intraepithelial lymphocyte migrationParthasarathy A, Fischer MA, Parkos CA, Edelblum KL.CD47Intestinal epithelium, mucosal immune surveillance10.64898/2026.08.19.7457592Moderate
Aug 28, 2026Piezo1 balances focal and reticular adhesions to enable EGFR clathrin-mediated endocytosisBagudanch O, Zoroa O, Ayala V, Midyan R, Bagley DC, Moparthi SB, Hakanpää L, Lenaerts A, Almeida-Souza L, Muñoz FJ, Valverde MA, Vassilopoulos S, Rosenblatt J, Pardo-Pastor C.EGFREpithelial cancers, EGFR trafficking10.64898/2026.08.21.7462501Mild
Aug 28, 2026Swedish APP follows distinct neuronal trafficking itineraries that underlie its increased Aβ-cleavagePlowinske CR, Tedesco S, Nabb AT, Quinones GB, Bentley M.APPAlzheimer's disease10.64898/2026.08.22.7460591Moderate
Aug 27, 2026NLRX1 is an essential, druggable regulator of mitochondrial permeability transitionPeltier-Heap R, Frederick DW, Pickering RJ, Ghidelli-Disse S, Searle K, Barber JC, Galwey N, Wilhelm LP, Triantafilou K, Triantafilou M, Wright O, Ramachandran S, Tan Y, Xia W, Aw C, Rivers E, Lacroix Y, Reddy E, Glover RP, Brunori G, Oon P, Broom AJ, Grimsditch D, Garcia A, Robertson A, Hirano K, Browne E, Drewes G, Ganley IG, Schroder K, Ahmed M, Booty LM.NLRX1Mitochondrial permeability transition, neurological injury10.64898/2026.08.24.7468601Mild
Aug 27, 2026A PTBP1-CDC42 splicing axis regulates leukemia growth and venetoclax sensitivity in acute myeloid leukemiaOberling M, Landry M, Aubert Y, Faivre M, Gay A, Boudet A, Granjon A, Sahal A, Bertoli S, Vergez F, Mansat-De Mas V, Recher C, Larrue C, Poillet L, Sarry J, Joffre C, Diaz-Munoz MD, Pancaldi V, Ghisi M.BCL2Acute myeloid leukemia10.64898/2026.08.25.7459541Mild
Aug 27, 2026VEGFR-2 Phosphorylation at Y1054 or Y1214 is Necessary for Mechanically-Induced AngiogenesisJohnson B, McKinley T, Nguyen T, Beasley-Duncan E, Gridhar T, Sewell-Loftin MK.KDRSolid tumour angiogenesis (tumour microenvironment mechanotransduction)10.64898/2026.08.21.7462253Strong
Aug 27, 2026An MLL-Independent Function of Menin Promotes Resistance to MAPK-Targeted TherapySrivaths A, AlHalawani A, Djajawi TM, Huber A, Gerak C, Jenkins L, Crake R, Needham K, Sen B, Rivera IS, Khoshdoozmasouleh N, Mielke LA, Neil L, Pal B, Mariadason JM, Kearney CJ, Vervoort SJ.MEN1BRAF-mutant colorectal cancer10.64898/2026.08.24.7460762Moderate
Aug 26, 2026Oncogene-Mechanics Axis: KRAS G12C Confers Agility Enabling Malignant Mechano-responses to Peristalsis in Colorectal CancerLamichhane, A.; Cheburkanov, V.; Kizilov, M.; Shenoy, A.; Head, A. G.; Yakovlev, V.; Raghavan, S. A.KRASColorectal cancer10.64898/2026.04.28.7214531Mild
Aug 26, 2026Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimer's diseaseArai, M.; Yue, J.; Shams, E.; Stevens, C. J.; Han, H.; Gibson, R.; Yildirim, T.; Feldman, H. H.; Wellington, C. L.; Kent, B. A.APPAlzheimer's disease10.64898/2026.08.20.7460361Moderate
Aug 26, 2026Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasisShim, K. H.; Ran, Y.; Ryu, D.; Moore, B.; Yook, Y.; Amin, P.; Liu, X.; Afroz, F.; Martin, C.; Beheray, M.; Tsering, W.; Liu, L.; Platt, M.; Roberts, B.; Seyfried, N.; Prokop, S.; Levites, Y.; Golde, T.APPAlzheimer's disease10.64898/2026.08.21.7439901Moderate
Aug 26, 2026Lipid anchor engineering controls cell-penetrating arginine-rich peptide presentation for efficient siEGFR liposomal delivery to triple-negative breast cancer cellsBialecki, P.; Braccia, S.; Makowski, T.; Piorecka, K.; Falcigno, L.; Bellavita, R.; Falanga, A.; Bryszewska, M.; Robaszkiewicz, A.; Galdiero, S.; Pedziwiatr-Werbicka, E.EGFRTriple-negative breast cancer10.64898/2026.08.20.7457051Mild
Aug 26, 2026IL-12 restores the sequential cytotoxic capacities of anti-GD2 CAR-T and CAR-iNKT cells against glioblastomaTran, T.-D.; Lamorlette, C.; Gerard, L.; Brouard, J.; Dotti, G.; Moulin, D.; Reppel, L.; Pochon, C.; Rubio, M.-T.IL12BGlioblastoma10.64898/2026.08.23.7465581Moderate
Aug 26, 2026Prefrontal cortex glucocorticoid receptors during fear memory consolidation shift the balance between salience and default-mode networks at retrieval in ratsdos Santos Correa, M.; Vido Lopes, L.; Quintiliano dos Santos, A. C.; Castro, J. C.; Boscariol Lourenco, W. T.; da Costa Silva, A. C.; Ferreira, T. L.; Tiba, P. A.; Fornari, R. V.NR3C1Post-traumatic stress disorder and fear memory generalisation10.64898/2026.08.21.7458922Moderate
Aug 26, 2026Glycogen Synthase Kinase-3β Regulates Cellular Prion Protein LevelsBeauchemin, K. S.; Schmoker, A. M.; Watts, J. C.; Supattapone, S.GSK3BPrion disease and Alzheimer's disease10.64898/2026.08.21.7461991Mild
Aug 26, 2026Membrane PI(4,5)P2 and ErbB2 abundance regulate ErbB receptor signaling through receptor oligomerization and activationAbe, M.; Yanagawa, M.; Sako, Y.ERBB2HER2-expressing solid tumours10.64898/2026.08.24.7466112Moderate
Aug 26, 2026Humanized APP is the primary determinant of regional brain volume in humanized APOE knock-in mice: a cross-sectional ex vivo MRI studyBhattrai, A.; Raikes, A. C.; Brinton, R. D.APPAlzheimer's disease10.64898/2026.05.04.7227641Moderate
Aug 2, 2026EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogrammingChildress, A. R.; Esoe, D.-P. I.; Song, X.; Gosser, C. M.; Lin, Y.; Plaugher, D. R.; DuCote, T. J.; Naughton, K. J.; Skaggs, E. M.; Yang, H.; Goettl, R.; Liu, J.; Hao, Z.; Fliss, A. E.; Honma, D.; Burus, T.; Lei, F.; Huang, B.; Beswick, E.; Brainson, C. F.PDCD1Lung squamous cell carcinoma10.64898/2026.06.01.7259561Moderate
Aug 1, 2026Deep Mechanistic Models reveal pathway-extrinsic drivers of mammary MAPK signalling heterogeneityFabrini, G.; Froehlich, F.EGFRBreast cancer cell line signalling heterogeneity10.64898/2026.07.30.7417591Mild
Aug 1, 2026A Multicenter Confirmatory Randomized-Controlled Study of rhNRGβ1 Protein Replacement Therapy in a Murine Model of NF2-related SchwannomatosisReuter, M.; Groth, S.; Schleep, J.; Riecken, L. B.; Schindler, L.; Jung, M. J.; Sundaram, V.; Cirri, E.; Poempner, N.; Wedekind, L.; Palm, J.; Scherag, A.; Stassart, R. M.; Fledrich, R.; Bauer, R.; Morrison, H.ERBB2NF2-related schwannomatosis10.64898/2026.07.31.7419632Moderate
Aug 1, 2026Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastasesKazi, A.; Cao, Y.; Mohindroo, C.; Joshi, A.; Zhang, Y.; Huang, Y.; Tabe, C.; Schroeder, B.; Andresson, T.; Sharma, A. K.; Thomas, A.LAG3Small-cell lung cancer liver metastases10.64898/2026.07.30.7418572Moderate
Aug 1, 2026Exploratory Network Analysis of Oral Bacteria Taste Signaling Autophagy Crosstalk in Oral Squamous Cell Carcinoma and Multi-Target Ligand Design for the MAPK1 STAT3 mTOR AxisAkhavan, M.; Latifi-Navid, S. G.; Barzegar Behrooz, A.; Vakili, S.; Vitorino, R.; Aftabi, S.; Peela, S.; Ponamgi, S.; Schroth, R. J.; Berumen, M.; Yuan, C.; Akbari Azirani, T.; Pecic, S.; Chelikani, P.; Ghavami, S.MAPK1Oral squamous cell carcinoma10.64898/2026.07.30.7418611Moderate
Aug 1, 2026Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and InflammationShabrish, S.; Patade, S.; Shinde, S.; Yelukar, R.; Raghuram, G. V.; Lopes, R.; Khare, N. K.; Mittra, I.STING1Sterile inflammation and DNA damage10.64898/2026.07.28.7411821Mild
Aug 1, 2026Gastrin releasing peptide and cholecystokinin employ different intracellular pathways to elicit similar safe Ca2+ signalsSalih, M.; Gerasimenko, J. V.; Gerasimenko, O. V.; Petersen, O. H.CD38Pancreatic acinar calcium signalling10.64898/2026.07.28.7412121Mild
Aug 1, 2026Meta-analyses of the NEPTUNE dataset related to high and low risk FSGS and cellular APOL1 models identifies Calcium signalling, mTOR signaling and inflammation-associated pathways as operative in APOL1-mediated kidney disease.Wruck, W.; Thimm, C.; Amin, T.; Somoano Sanchez, M. D.; Pulo, S.; Adjaye, J.MTORAPOL1-mediated kidney disease10.64898/2026.07.30.7417421Moderate
Jul 30, 2026DIANNeR: label-free RIME resolves lineage-restricted Glucocorticoid Receptor interactomes in normal human tissuesZhao, W.; Grimes, T. F.; Rose, S. F.; Stenning, J.; Taylor, C.; Baldreki, C.; Goulding, I.; Duke, R.; Baker, S. C.; Montes de Oca, M.; Sinha, A.; Hinley, J.; Fox, J. M.; Kaye, P. M.; Gomm, J. J.; Jones, L. J.; Marangoni, E.; Simoes, B. M.; Clarke, R. B.; Southgate, J.; Bridge, K. S.; Dowle, A.; Holding, A. N.NR3C1Normal and transformed breast, ureter and blood tissue10.1101/2025.08.07.6691661Moderate
Jul 30, 2026Endogenous single-cell experiments and stochastic modeling reveal control mechanisms of glucocorticoid receptor dynamics and DUSP1 transcriptionRon, E.; Popinga, A.; Forman, J.; Aguilera, L.; Forero, L.; Munsky, B.NR3C1Glucocorticoid-responsive inflammation10.64898/2026.07.01.7358841Moderate
Jul 30, 2026Structure and Function of TM6SF1 Reveal Role in mTORC1 SignalingHong, S.; Jia, L.; Wang, R.; Elghobashi-Meinhardt, N.; Hobbs, H. H.; Li, X.MTORNot specified in the preprint, lysosomal cholesterol signalling in cell models10.64898/2026.04.01.7159281Moderate
Jul 30, 2026Human blood vessel organoids reveal a critical role for IGFBP7 in Diabetic MicroangiopathyPooni, A.; Theofilatos, K.; Boas, L.; Pruktanakul, T.; Alhaque, S.; Romeo, S. G.; Secco, I.; Sneider, E.; Oexner, R.; Schmitt, R.; Zoccarato, A.; Park, S.-H.; Lynham, S.; Zeng, L.; Lee, C. N.; Jackson, T. L.; Modarai, B.; Margariti, A.; Giacca, M.; Shah, A. M.; Zampetaki, A.LGALS3Diabetic microangiopathy, diabetic nephropathy and diabetic retinopathy10.64898/2026.07.26.263587521Moderate
Jul 30, 2026A practical workflow for CAR screening in primary T cells using fitness-guided design and mRNA electroporationOkuma, A.; Ishida, Y.; Hisada, S.CD19CD19-positive haematological cancer10.64898/2026.07.28.7412071Moderate
Jul 30, 2026Hypergraph geometry localizes mutation-associated dependency vulnerabilities in cancer.Lee, J.; Lee, J.BRAFPrecision oncology across DepMap and Sanger cancer cell line cohorts10.64898/2026.07.26.7408121Mild
Jul 29, 2026Safety profiling of CAR-T cells using an organotypic human tissue platformMachado, A.; Birsen, G.; Rajnpreht, I.; Furtado Peter, I.; Colell, S.; Marzal, B.; Fredon, M.; Ziegler-Martin, K.; Martinez Bedoya, D.; Fumagalli, M.; Vimeux, L.; Davanture, S.; Melchiore, F.; Thomas, A.; Collet, M.; Fremand, X.; Burroni, B.; Laugel, B.; Lupo-Mansuet, A.; Prieto, M.; Damotte, D.; Le Doussal, J.-M.; Luu, M.; Dutoit, V.; Garnache-Ottou, F.; Guedan, S.; Migliorini, D.; Donnadieu, E.ERBB2HER2-expressing advanced solid tumours (on-target off-tumour toxicity in healthy lung tissue)10.64898/2026.07.25.7405272Moderate
Jul 29, 2026Gelsolin Counteracts ER Stress-Driven Inflammatory Circuits in Psoriasis-like DermatitisOri, D.; Okude, H.; Konishi, R.; Murase, M.; Hiroki, S.; Takahara, S.; Tanaka, T.; Toyodome, R.; Kano, N.; Kawasaki, T.; Ishii, K.; Kobiyama, K.; Nakashima, H.; Nakashima, K.; Sasai, M.; Yamamoto, M.; Kumagai, Y.; Tsuru, A.; Kohno, K.; Kawai, T.TLR9Psoriasis-like dermatitis10.1101/2025.11.20.6894132Moderate
Jul 29, 2026Network Pharmacology-Guided Discovery of Fungal Autophagy Modulators for Tauopathies: Structural and Proteomic EvidenceTorres Mc Cook, A. R.; Mimura, C. B.; Alvarez, L. D.; Liberman, A. C.GSK3BTauopathies10.64898/2026.07.24.7403671Mild
Jul 28, 2026Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast CancerLum, T. C. I.; Tan, J. Y. M.; Ng, F. J. H.; Leong, S. M.; Bin Masroni, M. S.; Hue, S. S. S.CD47Diffuse large B cell lymphoma and triple-negative breast cancer10.64898/2026.07.25.7406522Moderate
Jul 28, 2026Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstreamCabaud, O.; Aulas, A.; Lopresti, A. M.; Acquaviva, C.; Finetti, P.; Dessaux, C.; Ganier, L.; Da-Costa, Q.; Germier, C.; Mescam, L.; Elkaoutari, A.; Audebert, S.; Camoin, L.; de Rauglaudre, B.; Boudin, L.; Denicolai, E.; Lumet, G.; Cohendet, A.; Picard, M.; Birnbaum, D.; Gouarne, C.; Chanez, B.; De Chaisemartin, C.; Lelong, B.; Marchetto, S.; Goncalves, A.; Bertucci, F.; Borg, J.-P.; Mamessier, E.PTK7Colorectal cancer metastasis10.64898/2026.07.24.7405261Mild
Jul 28, 2026Neuropilin-1 functions as a proviral and immunoregulatory host factor during Chikungunya virus infectionTung, K. S.; Mahish, C.; Ghosh, S.; Mukherjee, K.; Singh, S.; Bhowmick, B.; Khamaru, S.; Borasi, H.; Gaur, M.; Subudhi, B. B.; Chattopadhyay, S.; Chattopadhyay, S.NRP1Chikungunya virus infection10.64898/2026.07.27.7410041Mild
Jul 28, 2026AKT1/mTOR/RICTOR risk variants in Indian hypertrophic cardiomyopathy patientsChittora, H.; Notani, D.; Dhandapany, P. S.MTORHypertrophic cardiomyopathy10.64898/2026.07.23.263587821Moderate
Jul 28, 2026Desialylated platelets promote hepatocyte proliferation via the ERK1/2 signaling pathwayNoboruo, I.; Nakamura, T.; Okumura, M.; Nishijima, T.; Inada, H.; Tanaka, Y.; Kawaguchi, T.; Matsuoka, M.; Yasunaga, J.-i.; Uchiba, M.; Kozuma, Y.MAPK1Liver regeneration and hepatocyte proliferation10.64898/2026.07.26.7402931Moderate
Jul 28, 2026Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed ImmunotherapyGottumukkala, N. V.; Loja, T.; Smida, M.CD19B cell malignancies treated with CD19-directed immunotherapy10.64898/2026.07.26.7407511Moderate
Jul 28, 2026A thalamostriatal brake counteracts cortical recruitment of striatal ensembles in levodopa-induced dyskinesiaWang, J.; Tu, X.-Y.; Liang, J.-X.; Sun, J.-Y.; Xu, W.; Wang, Y.; Yi, X.; Wu, Y.-J.; Li, X.-N.; Liu, Y.-X.; Liu, Z.; Li, W.-G.; Song, L.GRIN1Levodopa-induced dyskinesia10.64898/2026.07.22.7402231Moderate
Jul 27, 2026Dual stimulation of CD40 and 41BB pathways during ex-vivo TIL expansion enhances CD8+ T cell expansionMarques Rossetti, R. A.; S. Beatty, M.; Cianne, J.; R. Ali, J.; Harris, K.; Ramadan, A.; Grant, M.; Martinez Planes, E.; Aurelio, J.; Karapetyan, L.; Creelan, B.; Pilon-Thomas, S.; Hwu, P.; Luca, V. C.; Abate-Daga, D.CD40Melanoma and lung cancer, tumor-infiltrating lymphocyte therapy10.64898/2026.07.22.7401283Strong
Jul 27, 2026IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 ImmunitySochen, C.; Lebon, S.; Habshush-Menachem, A.; Sarusi-Portuguez, A.; Holiar, V.; Rudenko, V.; Toval, B.; Liu, J.; Levin, Y.; Vaaknin, E.; Rosenthal, N.; Tiferet, N.; Orr, I.; Ben-Dor, S.; Haffner-Krausz, R.; Grencis, R.; Munitz, A.; Karo-Atar, D.; Shulman, Z.; Biton, M.IL13Intestinal type 2 immunity10.64898/2026.07.24.7403761Moderate
Jul 27, 2026IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2Chadha, A. S.; Elahi, A.; Frey, B. F.; Nagaoka-Kamata, Y.; Zindl, C. L.; Schoeb, T. R.; Glassman, C. R.; Garcia, K. C.; Weaver, C. T.IL23AChronic autoimmune intestinal inflammation10.64898/2026.07.23.7403202Moderate
Jul 26, 2026Occurrence of Biased mTOR Signaling in Hepatocellular CarcinomaSingh, R.; Patel, N.; Singh, N.; Mourya, P.; Shingade, A.; Mange, A.; Kaur, J.; Beloshe, S.; Dudhalkar, A.; Chavan, P.; Yengkhom, G. D.; Patkar, S.; Goel, M.; Ingle, A.; Tripathy, S. R.; Epari, S.; Arandkar, S.; Thorat, R.; Shetty, S.MTORHepatocellular carcinoma10.64898/2026.05.22.7271881Moderate
Jul 26, 2026SynNotch receptors for visualizing immunoreceptor force transmission and downstream signaling in vivoLi, M.; Lyu, J.; Li, K.; Dravid, A.; Balasubramani, D.; Kazemipour Ashkezari, A. H.; Choi, H.-K.; Kwong, G. A.; Singh, A.; Zhu, C.CD40Solid tumor immune activation (CD40 and T cell receptor mechanosignaling)10.64898/2026.06.26.7345581Moderate
Jul 26, 2026Unveiling Gloriosine as a Dual-Acting Regulator of Glutamine Metabolism and Ferroptosis in Triple-Negative Breast Cancer: Insights from Network Pharmacology and Experimental ValidationDey, B.; Chatterjee, E.; Goel, B.; Jain, S. K.; Naik, P. K.; Guru, S. K.MTORTriple-negative breast cancer10.64898/2026.05.17.7253211Moderate
Jul 11, 2026Argininosuccinate Synthase 1 links hepatic urea cycle to whole body lipid metabolismKim, L. C.; Lesner, N. P.; Cai, X.; Han, X.; Jung, J. W.; Xu, J. P.; Coffey, N. J.; Zheng, D.; Brown, M. L.; Mesaros, C.; Arany, Z.; Simon, M. C.ASS1Hepatocellular carcinoma10.64898/2026.06.02.7296181Moderate
Jul 8, 2026CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immune competent, chemoresistant neuroblastoma preclinical modelsHimsworth, C.; Jackson, T.; Bowers, C.; Munnings-Tomes, S.; Nair, G.; Muller, H.; Tucker, E.; Erbe-Gurel, A. K.; Sondel, P.; Chesler, L.; Mazjner, R.; Anderson, J.CD47Neuroblastoma10.64898/2026.07.02.7360041Mild
Jul 6, 2026Peptide allosteric inhibitor of TNFR1 signaling attenuates inflammation and rheumatoid arthritis pathology in human TNF transgenic miceRiyed, T. H.; Kalary, K.; Zeng, J.; Lo, C. H.TNFRheumatoid arthritis10.64898/2026.06.30.7357041Moderate
Jul 6, 2026Kappa opioid receptors (KORs) in the anterior paraventricular nucleus of the thalamus (aPVT) mediate morphine withdrawal-, anxiety-, fear-, and KOR agonist-induced aversion-like behaviors in miceHuang, P.; Chen, C.; Bland, K.; Anand, A.; Beier, K.; Liu-Chen, L.-Y.OPRK1Kappa opioid receptor circuit in aversion and mood behaviors10.64898/2026.06.30.7356251Moderate
Jun 26, 2026Bispecific Antibody Architecture and TNFRSF Target Selection Determine CD8+ T Cell Differentiation and Anti-tumour ImmunityWiddess MA, Wilkinson L, Metcalfe HJ, Pakidi A, Chan HC, Kim J, Inzhelevskaya T, Turaj A, Lim SH, Thirdborough SM, Beers SA, Cragg MS, Al-Shamkhani ATNFRSF9Solid tumours (B7-H3-positive; CD8+ T cell co-stimulation)10.64898/2026.06.19.7326422Moderate
Jun 24, 2026AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid PathologyAbdel-Rahman, S.; Gabr, M.LILRB4Alzheimer's disease10.64898/2026.06.12.7318451Mild
Jun 24, 2026From DNA-Encoded Library (DEL) Screening to In Vivo Validation: LILRB4 (ILT3)-Targeted Small Molecules Reprograms Myeloid Immune SuppressionAbdel-Rahman, S.; Gabr, M.LILRB4Alzheimer's disease10.64898/2026.06.10.7312671Mild
Jun 20, 2026CRISPR/Cas9-based knockout screening revealed GSK3beta as a key regulator for structural plasticity of axon initial segmentDu, Y.; Egawa, R.; Adachi, R.; Motohara, K.; Furumichi, K.; Fukaya, R.; Kuba, H.GSK3B—10.64898/2026.05.21.7267871Mild
Jun 20, 2026Region-specific regulation of glucocorticoid and mineralocorticoid receptor signaling in a mouse model of oral contraceptive exposureSchuh, K. M.; Woock, M. G.; Vaandrager, M. J.; Romano, E. G.; He, Y.; Ludmir, D.; Tronson, N. C.NR3C1—10.64898/2026.06.15.7319331Moderate
Jun 17, 2026GPCR-mediated regulation of glial TNF productionStellwagen, D.; Abbasi, Z.; Sadighparvar, S.; Franquin, M.TNFGlial neuroinflammation (TNF regulation)10.64898/2026.06.12.7318541Moderate
Jun 17, 2026Effects of oxidative stress and aging on nerve, muscle, and synapse in a male-specific abdominal neuromuscular junction in DrosophilaUeda, A.; Wu, C.-F.SOD1Amyotrophic lateral sclerosis (SOD1 oxidative-stress model)10.64898/2026.06.10.7314801Moderate
Jun 15, 2026Systematic AI-Driven Drug Repurposing via Clinical Trial Data Mining: A Framework and Six Cross-Therapeutic Case Studies.Gote, V.TNFEarly-stage neurodegeneration (repurposing hypothesis)10.64898/2026.06.11.7316291Moderate
Jun 12, 2026Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS miceMot, A. I.; Li, Y.; Dibaj, P.; Tzvetanova, I. D.; Gerwig, U. C.; Bogale, T. A.; Goebbels, S.; Möbius, W.; Bergles, D. E.; Morrison, B. M.; Rothstein, J. D.; Cleveland, D. W.; Edgar, J. M.; Nave, K.-A.SOD1Amyotrophic lateral sclerosis (familial, SOD1-mutant)10.64898/2026.06.09.7311001Moderate
Jun 11, 2026Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast CancerEder, I.; Baghaei, M.; Maurya, S.; Yu, V.; Wilson, E.; Kashkoush, A.; Liu, J.-J.; Liu, S.; Luo, J.; Storkus, W.; Roy, P.STING1Breast cancer10.64898/2026.06.05.7303621Mild
Jun 11, 2026Receptor-structured modelling of EGFR-driven tumor initiation: from spatially resolved cell-based simulations to reduced population dynamicsQasim, R.; BOUCHNITA, A.EGFREGFR-driven tumor initiation (solid tumor)10.64898/2026.06.05.7305291Mild
Jun 9, 2026Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem CellsRodgers, K. A.; Garfinkle, E. A.; Kigerl, K. A.; Asghari, E.; Mifflin, K. A.; Hall, J.; Kulkarni, R.; Wang, C.; Goda, C.; Rodrigues Dias, A. C.; Guan, Z.; Karunasiri, M.; Ma, Q.; Miller, K. E.; Dorrance, A.; Popovich, P. G.NR3C1Spinal cord injury (hematopoietic stem cell failure)10.1101/2025.10.05.6805351Moderate
Jun 7, 2026Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype PenetranceHeinrich, P.; Jung, R. M.; Achter, J. S.; Nguyen, V. X.; Lee, C. A.; Sailer, C.; Domian, H.; Vander Roest, A. S.; Suchy, F. P.; Jahng, J. W.; Kojic, A.; Lee, D.; Paasche, A.; Roberts, B.; Nakauchi, H.; Zhu, H.; Wu, J. C.; Bernstein, D.; Moretti, A.; Lundby, A.; Lee, S.; Wu, S. M.MYH7Hypertrophic cardiomyopathy10.64898/2026.06.02.7294111Mild
Jun 7, 2026Uncovering moonlighting role of mitochondrial presequence translocase machinery in SOD1-mediated ALS pathogenesisWaingankar, T. P.; Paliwal, A.; Deep, A.; D'Silva, P.SOD1Amyotrophic lateral sclerosis (SOD1)10.64898/2026.06.03.7297911Moderate
Jun 6, 2026EGFR Inhibition Promotes Enteroendocrine Cell Differentiation Contributing To Treatment-Associated DiarrheaRamos, G. P.; Zeve, D.; Shepherd, A.; Saint-Denis, E.; Aldefer, O.; Frintu, B.; Dale, S.; Sharma, K.; Mohlmann, E.; Mannam, P.; Byers, M.; Terzian, J.; Ribeiro, C. D.; Silva Oliveira, L. F.; Borges, K. S.; O'Connell, A. E.; Carlone, D.; Florez, N.; Rao, M. E.; Breault, D. P.EGFRTreatment-associated diarrhea (EGFR inhibition)10.64898/2026.06.02.7296501Mild
Jun 5, 2026Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomasDas, D.; Pandele, A.; Jariwala, V. D.; Ghariwala, N. S.; Mohammed, A. O.; Das, T.; Krolla, C.; Arosh, S. M.; Hossain, N.; Shhab, M. A.; Hosen, I.; Smith, S. J.; Grauvogel, J.; Vasilikos, I.; Roelz, R.; Nakgawa, J.; Hoefllin, R.; Tirosh, I.; Juratli, T.; Schneider, M.; Prinz, M.; Hervey-Jumper, S.; Rahman, R.; Boerries, M.; Beck, J.; Jospeh, K.; Andrieux, G.; Ravi, V. M.; Chakraborty, S.EGFRIDH-mutant glioma10.64898/2026.05.31.7291051Mild
Jun 3, 2026CD96-mediated internalisation of ligand CD155 as a novel mechanism for immune regulationShinko, D.; Ford, R. A.; Kos, M.; Attrill, M. H.; Wu, R.; Spector, R.; Pesenacker, A. M.TIGITSolid tumor immune regulation (CD155 / TIGIT axis)10.64898/2026.05.29.7278531Moderate
Jun 3, 2026Long-read Oxford Nanopore sequencing reveals complex rearrangements and regulatory disruption in malignant pleural mesotheliomaAlhazmi, M. H.; Poile, C.; Dzialo, J.; Bzura, A.; Kutywayo, K.; Fennell, D.; Hollox, E. J.WEE1Malignant pleural mesothelioma10.64898/2026.05.26.263538641Mild
Jun 2, 2026AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung InjurySoetopo D, Mayr CH, Fundel-Clemens K, Ramirez F, Viollet C, Dick A, Rust W, Santacruz D, Hoevels Y, Applebee CJ, Legg S, Funk A, Schnapp G, Padget J, Strobel B, Thomas MJ, Ward SG, Larijani B, Geillinger-Kaestle KAXLIdiopathic pulmonary fibrosis10.1101/2025.04.07.6475671Mild
May 25, 2026Reactivation of DRP1 plays a functional role in resistance to MEK inhibition in pancreatic cancer cellsSharmin, S.; Kashatus, J. A.; Adair, S. J.; Bakall Loewgren, E.; Fallahi-Sichani, M.; Bauer, T. W.; Kashatus, D.CDK6Pancreatic ductal adenocarcinoma (PDAC), KRAS-driven10.64898/2026.05.20.7266632Moderate
May 24, 2026Time-Resolved Phosphoproteomics-Guided BFS Beam Search Reveals Cell-Type-Specific EGFR Signaling Architectures and SHP2 Inhibitor-Induced Pathway RewiringLee, H.; Lee, G.EGFRSolid tumors with EGFR-driven signaling10.64898/2026.03.20.7127751Mild
May 24, 2026Lapatinib Suppressed the Expression of Proinflammatory Cytokines and Alleviated Pain Behavior in a Mouse Model of Postoperative PainKyomuhangi, A.TNFPostoperative inflammatory pain (model)10.64898/2026.01.07.6982121Moderate
May 22, 2026TKI-Tolerant Persisters Emerge from a PKCα-Dependent and Highly Plastic Subpopulation of Stem-Like Cells in NSCLCSadeghi, M.; Salama, M.; Choudhury, S.; Huang, A.; Yang, J.; Hannun, Y. A.EGFREGFR-mutant non-small cell lung carcinoma10.64898/2026.05.20.7264971Mild
May 22, 2026Genotype-Dependent Dysregulation of the MDM2-p53 Axis and Breast Cancer Susceptibility in Bangladeshi Women: A Cas-Control StudyChowdhury, M. H.; Islam, F.; Khan, A. A.; Siddique, M. A.; Hasan, N. B.; Samrat, M. I.; Tanisha, M. H.; Tasnim, J.; Mahjabin, S.; Islam, M. N.; Haque, M. A.MDM2Breast cancer10.64898/2026.05.18.7261001Mild
May 21, 2026Cytokine storm dynamics in hantavirus pulmonary syndrome: a multiscale ODE model with Wasserstein early-warning score and application to the 2026 Andes virus outbreakdes Rochettes, B.TNFHantavirus pulmonary syndrome (acute respiratory failure)10.64898/2026.05.15.263532861Moderate
May 20, 2026Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal developmentGriffiths, K. M.; Armstrong, J.; Martin, N.; Murray Lawson, C.; Oneil, E.; David, L. S.; Temi, S.; Parnell, J.; Rudyk, C.; Bursey, J.; Krajewski, J. L.; McDermott, J. S.; Dedek, A.; Levine, A. J.; Li, B.; Tsai, E. C.; Hildebrand, M. E.GRIN2BMajor Depressive Disorder with Suicidal Ideation with Intent10.1101/2025.10.22.6839151Moderate
May 20, 2026An 8 Gene Bevacizumab Resistance Signature Predicts Prognosis and Reveals Immunosuppressive Microenvironment in Colorectal CancerNiu, Z.; Qiu, D.; Xu, P.TNFCOVID-19 acute respiratory distress10.64898/2026.05.17.7257491Moderate