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Preprint Watch

Daily automated cross-reference of new bioRxiv preprints against the indexed clinical failure record.

Strong contradictions

0

3+ failures or Phase 3 efficacy failure

Moderate contradictions

4

2 failures or single Phase 3 failure

Mild contradictions

3

1 failure (Phase 1 or 2)

7 flags indexed
PreprintDiseaseDOI
May 24, 2026Time-Resolved Phosphoproteomics-Guided BFS Beam Search Reveals Cell-Type-Specific EGFR Signaling Architectures and SHP2 Inhibitor-Induced Pathway RewiringLee, H.; Lee, G.EGFRSolid tumors with EGFR-driven signaling10.64898/2026.03.20.7127751Mild
May 24, 2026Lapatinib Suppressed the Expression of Proinflammatory Cytokines and Alleviated Pain Behavior in a Mouse Model of Postoperative PainKyomuhangi, A.TNFPostoperative inflammatory pain (model)10.64898/2026.01.07.6982121Moderate
May 22, 2026TKI-Tolerant Persisters Emerge from a PKCα-Dependent and Highly Plastic Subpopulation of Stem-Like Cells in NSCLCSadeghi, M.; Salama, M.; Choudhury, S.; Huang, A.; Yang, J.; Hannun, Y. A.EGFREGFR-mutant non-small cell lung carcinoma10.64898/2026.05.20.7264971Mild
May 22, 2026Genotype-Dependent Dysregulation of the MDM2-p53 Axis and Breast Cancer Susceptibility in Bangladeshi Women: A Cas-Control StudyChowdhury, M. H.; Islam, F.; Khan, A. A.; Siddique, M. A.; Hasan, N. B.; Samrat, M. I.; Tanisha, M. H.; Tasnim, J.; Mahjabin, S.; Islam, M. N.; Haque, M. A.MDM2Breast cancer10.64898/2026.05.18.7261001Mild
May 21, 2026Cytokine storm dynamics in hantavirus pulmonary syndrome: a multiscale ODE model with Wasserstein early-warning score and application to the 2026 Andes virus outbreakdes Rochettes, B.TNFHantavirus pulmonary syndrome (acute respiratory failure)10.64898/2026.05.15.263532861Moderate
May 20, 2026Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal developmentGriffiths, K. M.; Armstrong, J.; Martin, N.; Murray Lawson, C.; Oneil, E.; David, L. S.; Temi, S.; Parnell, J.; Rudyk, C.; Bursey, J.; Krajewski, J. L.; McDermott, J. S.; Dedek, A.; Levine, A. J.; Li, B.; Tsai, E. C.; Hildebrand, M. E.GRIN2BMajor Depressive Disorder with Suicidal Ideation with Intent10.1101/2025.10.22.6839151Moderate
May 20, 2026An 8 Gene Bevacizumab Resistance Signature Predicts Prognosis and Reveals Immunosuppressive Microenvironment in Colorectal CancerNiu, Z.; Qiu, D.; Xu, P.TNFCOVID-19 acute respiratory distress10.64898/2026.05.17.7257491Moderate