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Preprint Watch

Daily automated cross-reference of new bioRxiv preprints against the indexed clinical failure record.

Strong contradictions

0

3+ failures or Phase 3 efficacy failure

Moderate contradictions

16

2 failures or single Phase 3 failure

Mild contradictions

14

1 failure (Phase 1 or 2)

30 flags indexed
PreprintDiseaseDOI
Jul 8, 2026CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immune competent, chemoresistant neuroblastoma preclinical modelsHimsworth, C.; Jackson, T.; Bowers, C.; Munnings-Tomes, S.; Nair, G.; Muller, H.; Tucker, E.; Erbe-Gurel, A. K.; Sondel, P.; Chesler, L.; Mazjner, R.; Anderson, J.CD47Neuroblastoma10.64898/2026.07.02.7360041Mild
Jul 6, 2026Peptide allosteric inhibitor of TNFR1 signaling attenuates inflammation and rheumatoid arthritis pathology in human TNF transgenic miceRiyed, T. H.; Kalary, K.; Zeng, J.; Lo, C. H.TNFRheumatoid arthritis10.64898/2026.06.30.7357041Moderate
Jul 6, 2026Kappa opioid receptors (KORs) in the anterior paraventricular nucleus of the thalamus (aPVT) mediate morphine withdrawal-, anxiety-, fear-, and KOR agonist-induced aversion-like behaviors in miceHuang, P.; Chen, C.; Bland, K.; Anand, A.; Beier, K.; Liu-Chen, L.-Y.OPRK1Kappa opioid receptor circuit in aversion and mood behaviors10.64898/2026.06.30.7356251Moderate
Jun 26, 2026Bispecific Antibody Architecture and TNFRSF Target Selection Determine CD8+ T Cell Differentiation and Anti-tumour ImmunityWiddess MA, Wilkinson L, Metcalfe HJ, Pakidi A, Chan HC, Kim J, Inzhelevskaya T, Turaj A, Lim SH, Thirdborough SM, Beers SA, Cragg MS, Al-Shamkhani ATNFRSF9Solid tumours (B7-H3-positive; CD8+ T cell co-stimulation)10.64898/2026.06.19.7326422Moderate
Jun 24, 2026AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid PathologyAbdel-Rahman, S.; Gabr, M.LILRB4Alzheimer's disease10.64898/2026.06.12.7318451Mild
Jun 24, 2026From DNA-Encoded Library (DEL) Screening to In Vivo Validation: LILRB4 (ILT3)-Targeted Small Molecules Reprograms Myeloid Immune SuppressionAbdel-Rahman, S.; Gabr, M.LILRB4Alzheimer's disease10.64898/2026.06.10.7312671Mild
Jun 20, 2026CRISPR/Cas9-based knockout screening revealed GSK3beta as a key regulator for structural plasticity of axon initial segmentDu, Y.; Egawa, R.; Adachi, R.; Motohara, K.; Furumichi, K.; Fukaya, R.; Kuba, H.GSK3B—10.64898/2026.05.21.7267871Mild
Jun 20, 2026Region-specific regulation of glucocorticoid and mineralocorticoid receptor signaling in a mouse model of oral contraceptive exposureSchuh, K. M.; Woock, M. G.; Vaandrager, M. J.; Romano, E. G.; He, Y.; Ludmir, D.; Tronson, N. C.NR3C1—10.64898/2026.06.15.7319331Moderate
Jun 17, 2026GPCR-mediated regulation of glial TNF productionStellwagen, D.; Abbasi, Z.; Sadighparvar, S.; Franquin, M.TNFGlial neuroinflammation (TNF regulation)10.64898/2026.06.12.7318541Moderate
Jun 17, 2026Effects of oxidative stress and aging on nerve, muscle, and synapse in a male-specific abdominal neuromuscular junction in DrosophilaUeda, A.; Wu, C.-F.SOD1Amyotrophic lateral sclerosis (SOD1 oxidative-stress model)10.64898/2026.06.10.7314801Moderate
Jun 15, 2026Systematic AI-Driven Drug Repurposing via Clinical Trial Data Mining: A Framework and Six Cross-Therapeutic Case Studies.Gote, V.TNFEarly-stage neurodegeneration (repurposing hypothesis)10.64898/2026.06.11.7316291Moderate
Jun 12, 2026Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS miceMot, A. I.; Li, Y.; Dibaj, P.; Tzvetanova, I. D.; Gerwig, U. C.; Bogale, T. A.; Goebbels, S.; Möbius, W.; Bergles, D. E.; Morrison, B. M.; Rothstein, J. D.; Cleveland, D. W.; Edgar, J. M.; Nave, K.-A.SOD1Amyotrophic lateral sclerosis (familial, SOD1-mutant)10.64898/2026.06.09.7311001Moderate
Jun 11, 2026Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast CancerEder, I.; Baghaei, M.; Maurya, S.; Yu, V.; Wilson, E.; Kashkoush, A.; Liu, J.-J.; Liu, S.; Luo, J.; Storkus, W.; Roy, P.STING1Breast cancer10.64898/2026.06.05.7303621Mild
Jun 11, 2026Receptor-structured modelling of EGFR-driven tumor initiation: from spatially resolved cell-based simulations to reduced population dynamicsQasim, R.; BOUCHNITA, A.EGFREGFR-driven tumor initiation (solid tumor)10.64898/2026.06.05.7305291Mild
Jun 9, 2026Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem CellsRodgers, K. A.; Garfinkle, E. A.; Kigerl, K. A.; Asghari, E.; Mifflin, K. A.; Hall, J.; Kulkarni, R.; Wang, C.; Goda, C.; Rodrigues Dias, A. C.; Guan, Z.; Karunasiri, M.; Ma, Q.; Miller, K. E.; Dorrance, A.; Popovich, P. G.NR3C1Spinal cord injury (hematopoietic stem cell failure)10.1101/2025.10.05.6805351Moderate
Jun 7, 2026Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype PenetranceHeinrich, P.; Jung, R. M.; Achter, J. S.; Nguyen, V. X.; Lee, C. A.; Sailer, C.; Domian, H.; Vander Roest, A. S.; Suchy, F. P.; Jahng, J. W.; Kojic, A.; Lee, D.; Paasche, A.; Roberts, B.; Nakauchi, H.; Zhu, H.; Wu, J. C.; Bernstein, D.; Moretti, A.; Lundby, A.; Lee, S.; Wu, S. M.MYH7Hypertrophic cardiomyopathy10.64898/2026.06.02.7294111Mild
Jun 7, 2026Uncovering moonlighting role of mitochondrial presequence translocase machinery in SOD1-mediated ALS pathogenesisWaingankar, T. P.; Paliwal, A.; Deep, A.; D'Silva, P.SOD1Amyotrophic lateral sclerosis (SOD1)10.64898/2026.06.03.7297911Moderate
Jun 6, 2026EGFR Inhibition Promotes Enteroendocrine Cell Differentiation Contributing To Treatment-Associated DiarrheaRamos, G. P.; Zeve, D.; Shepherd, A.; Saint-Denis, E.; Aldefer, O.; Frintu, B.; Dale, S.; Sharma, K.; Mohlmann, E.; Mannam, P.; Byers, M.; Terzian, J.; Ribeiro, C. D.; Silva Oliveira, L. F.; Borges, K. S.; O'Connell, A. E.; Carlone, D.; Florez, N.; Rao, M. E.; Breault, D. P.EGFRTreatment-associated diarrhea (EGFR inhibition)10.64898/2026.06.02.7296501Mild
Jun 5, 2026Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomasDas, D.; Pandele, A.; Jariwala, V. D.; Ghariwala, N. S.; Mohammed, A. O.; Das, T.; Krolla, C.; Arosh, S. M.; Hossain, N.; Shhab, M. A.; Hosen, I.; Smith, S. J.; Grauvogel, J.; Vasilikos, I.; Roelz, R.; Nakgawa, J.; Hoefllin, R.; Tirosh, I.; Juratli, T.; Schneider, M.; Prinz, M.; Hervey-Jumper, S.; Rahman, R.; Boerries, M.; Beck, J.; Jospeh, K.; Andrieux, G.; Ravi, V. M.; Chakraborty, S.EGFRIDH-mutant glioma10.64898/2026.05.31.7291051Mild
Jun 3, 2026CD96-mediated internalisation of ligand CD155 as a novel mechanism for immune regulationShinko, D.; Ford, R. A.; Kos, M.; Attrill, M. H.; Wu, R.; Spector, R.; Pesenacker, A. M.TIGITSolid tumor immune regulation (CD155 / TIGIT axis)10.64898/2026.05.29.7278531Moderate
Jun 3, 2026Long-read Oxford Nanopore sequencing reveals complex rearrangements and regulatory disruption in malignant pleural mesotheliomaAlhazmi, M. H.; Poile, C.; Dzialo, J.; Bzura, A.; Kutywayo, K.; Fennell, D.; Hollox, E. J.WEE1Malignant pleural mesothelioma10.64898/2026.05.26.263538641Mild
Jun 2, 2026AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung InjurySoetopo D, Mayr CH, Fundel-Clemens K, Ramirez F, Viollet C, Dick A, Rust W, Santacruz D, Hoevels Y, Applebee CJ, Legg S, Funk A, Schnapp G, Padget J, Strobel B, Thomas MJ, Ward SG, Larijani B, Geillinger-Kaestle KAXLIdiopathic pulmonary fibrosis10.1101/2025.04.07.6475671Mild
May 25, 2026Reactivation of DRP1 plays a functional role in resistance to MEK inhibition in pancreatic cancer cellsSharmin, S.; Kashatus, J. A.; Adair, S. J.; Bakall Loewgren, E.; Fallahi-Sichani, M.; Bauer, T. W.; Kashatus, D.CDK6Pancreatic ductal adenocarcinoma (PDAC), KRAS-driven10.64898/2026.05.20.7266632Moderate
May 24, 2026Time-Resolved Phosphoproteomics-Guided BFS Beam Search Reveals Cell-Type-Specific EGFR Signaling Architectures and SHP2 Inhibitor-Induced Pathway RewiringLee, H.; Lee, G.EGFRSolid tumors with EGFR-driven signaling10.64898/2026.03.20.7127751Mild
May 24, 2026Lapatinib Suppressed the Expression of Proinflammatory Cytokines and Alleviated Pain Behavior in a Mouse Model of Postoperative PainKyomuhangi, A.TNFPostoperative inflammatory pain (model)10.64898/2026.01.07.6982121Moderate
May 22, 2026TKI-Tolerant Persisters Emerge from a PKCα-Dependent and Highly Plastic Subpopulation of Stem-Like Cells in NSCLCSadeghi, M.; Salama, M.; Choudhury, S.; Huang, A.; Yang, J.; Hannun, Y. A.EGFREGFR-mutant non-small cell lung carcinoma10.64898/2026.05.20.7264971Mild
May 22, 2026Genotype-Dependent Dysregulation of the MDM2-p53 Axis and Breast Cancer Susceptibility in Bangladeshi Women: A Cas-Control StudyChowdhury, M. H.; Islam, F.; Khan, A. A.; Siddique, M. A.; Hasan, N. B.; Samrat, M. I.; Tanisha, M. H.; Tasnim, J.; Mahjabin, S.; Islam, M. N.; Haque, M. A.MDM2Breast cancer10.64898/2026.05.18.7261001Mild
May 21, 2026Cytokine storm dynamics in hantavirus pulmonary syndrome: a multiscale ODE model with Wasserstein early-warning score and application to the 2026 Andes virus outbreakdes Rochettes, B.TNFHantavirus pulmonary syndrome (acute respiratory failure)10.64898/2026.05.15.263532861Moderate
May 20, 2026Expression and localization of NMDA receptor GluN2 subunits in dorsal horn pain circuits across sex, species, and late postnatal developmentGriffiths, K. M.; Armstrong, J.; Martin, N.; Murray Lawson, C.; Oneil, E.; David, L. S.; Temi, S.; Parnell, J.; Rudyk, C.; Bursey, J.; Krajewski, J. L.; McDermott, J. S.; Dedek, A.; Levine, A. J.; Li, B.; Tsai, E. C.; Hildebrand, M. E.GRIN2BMajor Depressive Disorder with Suicidal Ideation with Intent10.1101/2025.10.22.6839151Moderate
May 20, 2026An 8 Gene Bevacizumab Resistance Signature Predicts Prognosis and Reveals Immunosuppressive Microenvironment in Colorectal CancerNiu, Z.; Qiu, D.; Xu, P.TNFCOVID-19 acute respiratory distress10.64898/2026.05.17.7257491Moderate