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Preprint Watch

Daily automated cross-reference of new bioRxiv preprints against the indexed clinical failure record.

Strong contradictions

1

3+ failures or Phase 3 efficacy failure

Moderate contradictions

45

2 failures or single Phase 3 failure

Mild contradictions

24

1 failure (Phase 1 or 2)

70 flags indexed
PreprintDiseaseDOI
Aug 26, 2026Oncogene-Mechanics Axis: KRAS G12C Confers Agility Enabling Malignant Mechano-responses to Peristalsis in Colorectal CancerLamichhane, A.; Cheburkanov, V.; Kizilov, M.; Shenoy, A.; Head, A. G.; Yakovlev, V.; Raghavan, S. A.KRASColorectal cancer10.64898/2026.04.28.7214531Mild
Aug 26, 2026Chronic trazodone treatment consolidates sleep, improves memory, and reduces amyloid pathology in a mouse model of Alzheimer's diseaseArai, M.; Yue, J.; Shams, E.; Stevens, C. J.; Han, H.; Gibson, R.; Yildirim, T.; Feldman, H. H.; Wellington, C. L.; Kent, B. A.APPAlzheimer's disease10.64898/2026.08.20.7460361Moderate
Aug 26, 2026Syndecan-4 exerts canonical heparan sulfate-dependent and noncanonical heparan sulfate-independent functions that regulate Aβ amyloid homeostasisShim, K. H.; Ran, Y.; Ryu, D.; Moore, B.; Yook, Y.; Amin, P.; Liu, X.; Afroz, F.; Martin, C.; Beheray, M.; Tsering, W.; Liu, L.; Platt, M.; Roberts, B.; Seyfried, N.; Prokop, S.; Levites, Y.; Golde, T.APPAlzheimer's disease10.64898/2026.08.21.7439901Moderate
Aug 26, 2026Lipid anchor engineering controls cell-penetrating arginine-rich peptide presentation for efficient siEGFR liposomal delivery to triple-negative breast cancer cellsBialecki, P.; Braccia, S.; Makowski, T.; Piorecka, K.; Falcigno, L.; Bellavita, R.; Falanga, A.; Bryszewska, M.; Robaszkiewicz, A.; Galdiero, S.; Pedziwiatr-Werbicka, E.EGFRTriple-negative breast cancer10.64898/2026.08.20.7457051Mild
Aug 26, 2026IL-12 restores the sequential cytotoxic capacities of anti-GD2 CAR-T and CAR-iNKT cells against glioblastomaTran, T.-D.; Lamorlette, C.; Gerard, L.; Brouard, J.; Dotti, G.; Moulin, D.; Reppel, L.; Pochon, C.; Rubio, M.-T.IL12BGlioblastoma10.64898/2026.08.23.7465581Moderate
Aug 26, 2026Prefrontal cortex glucocorticoid receptors during fear memory consolidation shift the balance between salience and default-mode networks at retrieval in ratsdos Santos Correa, M.; Vido Lopes, L.; Quintiliano dos Santos, A. C.; Castro, J. C.; Boscariol Lourenco, W. T.; da Costa Silva, A. C.; Ferreira, T. L.; Tiba, P. A.; Fornari, R. V.NR3C1Post-traumatic stress disorder and fear memory generalisation10.64898/2026.08.21.7458922Moderate
Aug 26, 2026Humanized APP is the primary determinant of regional brain volume in humanized APOE knock-in mice: a cross-sectional ex vivo MRI studyBhattrai, A.; Raikes, A. C.; Brinton, R. D.APPAlzheimer's disease10.64898/2026.05.04.7227641Moderate
Aug 26, 2026Membrane PI(4,5)P2 and ErbB2 abundance regulate ErbB receptor signaling through receptor oligomerization and activationAbe, M.; Yanagawa, M.; Sako, Y.ERBB2HER2-expressing solid tumours10.64898/2026.08.24.7466112Moderate
Aug 26, 2026Glycogen Synthase Kinase-3β Regulates Cellular Prion Protein LevelsBeauchemin, K. S.; Schmoker, A. M.; Watts, J. C.; Supattapone, S.GSK3BPrion disease and Alzheimer's disease10.64898/2026.08.21.7461991Mild
Aug 2, 2026EZH1/2 inhibition improves immunotherapy response through MHC Class II de-repression and neutrophil reprogrammingChildress, A. R.; Esoe, D.-P. I.; Song, X.; Gosser, C. M.; Lin, Y.; Plaugher, D. R.; DuCote, T. J.; Naughton, K. J.; Skaggs, E. M.; Yang, H.; Goettl, R.; Liu, J.; Hao, Z.; Fliss, A. E.; Honma, D.; Burus, T.; Lei, F.; Huang, B.; Beswick, E.; Brainson, C. F.PDCD1Lung squamous cell carcinoma10.64898/2026.06.01.7259561Moderate
Aug 1, 2026Tumor-hepatocyte crosstalk drives a hepatic lactate-TGF-β axis of CD8⁺ T cell exhaustion and immunotherapy resistance in small-cell lung cancer liver metastasesKazi, A.; Cao, Y.; Mohindroo, C.; Joshi, A.; Zhang, Y.; Huang, Y.; Tabe, C.; Schroeder, B.; Andresson, T.; Sharma, A. K.; Thomas, A.LAG3Small-cell lung cancer liver metastases10.64898/2026.07.30.7418572Moderate
Aug 1, 2026Circulating Cell-Free Chromatin Particles Trigger a Unique Biphasic STING Signaling Program that Drives DNA Damage and InflammationShabrish, S.; Patade, S.; Shinde, S.; Yelukar, R.; Raghuram, G. V.; Lopes, R.; Khare, N. K.; Mittra, I.STING1Sterile inflammation and DNA damage10.64898/2026.07.28.7411821Mild
Aug 1, 2026Gastrin releasing peptide and cholecystokinin employ different intracellular pathways to elicit similar safe Ca2+ signalsSalih, M.; Gerasimenko, J. V.; Gerasimenko, O. V.; Petersen, O. H.CD38Pancreatic acinar calcium signalling10.64898/2026.07.28.7412121Mild
Aug 1, 2026Meta-analyses of the NEPTUNE dataset related to high and low risk FSGS and cellular APOL1 models identifies Calcium signalling, mTOR signaling and inflammation-associated pathways as operative in APOL1-mediated kidney disease.Wruck, W.; Thimm, C.; Amin, T.; Somoano Sanchez, M. D.; Pulo, S.; Adjaye, J.MTORAPOL1-mediated kidney disease10.64898/2026.07.30.7417421Moderate
Aug 1, 2026A Multicenter Confirmatory Randomized-Controlled Study of rhNRGβ1 Protein Replacement Therapy in a Murine Model of NF2-related SchwannomatosisReuter, M.; Groth, S.; Schleep, J.; Riecken, L. B.; Schindler, L.; Jung, M. J.; Sundaram, V.; Cirri, E.; Poempner, N.; Wedekind, L.; Palm, J.; Scherag, A.; Stassart, R. M.; Fledrich, R.; Bauer, R.; Morrison, H.ERBB2NF2-related schwannomatosis10.64898/2026.07.31.7419632Moderate
Aug 1, 2026Exploratory Network Analysis of Oral Bacteria Taste Signaling Autophagy Crosstalk in Oral Squamous Cell Carcinoma and Multi-Target Ligand Design for the MAPK1 STAT3 mTOR AxisAkhavan, M.; Latifi-Navid, S. G.; Barzegar Behrooz, A.; Vakili, S.; Vitorino, R.; Aftabi, S.; Peela, S.; Ponamgi, S.; Schroth, R. J.; Berumen, M.; Yuan, C.; Akbari Azirani, T.; Pecic, S.; Chelikani, P.; Ghavami, S.MAPK1Oral squamous cell carcinoma10.64898/2026.07.30.7418611Moderate
Aug 1, 2026Deep Mechanistic Models reveal pathway-extrinsic drivers of mammary MAPK signalling heterogeneityFabrini, G.; Froehlich, F.EGFRBreast cancer cell line signalling heterogeneity10.64898/2026.07.30.7417591Mild
Jul 30, 2026DIANNeR: label-free RIME resolves lineage-restricted Glucocorticoid Receptor interactomes in normal human tissuesZhao, W.; Grimes, T. F.; Rose, S. F.; Stenning, J.; Taylor, C.; Baldreki, C.; Goulding, I.; Duke, R.; Baker, S. C.; Montes de Oca, M.; Sinha, A.; Hinley, J.; Fox, J. M.; Kaye, P. M.; Gomm, J. J.; Jones, L. J.; Marangoni, E.; Simoes, B. M.; Clarke, R. B.; Southgate, J.; Bridge, K. S.; Dowle, A.; Holding, A. N.NR3C1Normal and transformed breast, ureter and blood tissue10.1101/2025.08.07.6691661Moderate
Jul 30, 2026Structure and Function of TM6SF1 Reveal Role in mTORC1 SignalingHong, S.; Jia, L.; Wang, R.; Elghobashi-Meinhardt, N.; Hobbs, H. H.; Li, X.MTORNot specified in the preprint, lysosomal cholesterol signalling in cell models10.64898/2026.04.01.7159281Moderate
Jul 30, 2026Human blood vessel organoids reveal a critical role for IGFBP7 in Diabetic MicroangiopathyPooni, A.; Theofilatos, K.; Boas, L.; Pruktanakul, T.; Alhaque, S.; Romeo, S. G.; Secco, I.; Sneider, E.; Oexner, R.; Schmitt, R.; Zoccarato, A.; Park, S.-H.; Lynham, S.; Zeng, L.; Lee, C. N.; Jackson, T. L.; Modarai, B.; Margariti, A.; Giacca, M.; Shah, A. M.; Zampetaki, A.LGALS3Diabetic microangiopathy, diabetic nephropathy and diabetic retinopathy10.64898/2026.07.26.263587521Moderate
Jul 30, 2026Hypergraph geometry localizes mutation-associated dependency vulnerabilities in cancer.Lee, J.; Lee, J.BRAFPrecision oncology across DepMap and Sanger cancer cell line cohorts10.64898/2026.07.26.7408121Mild
Jul 30, 2026A practical workflow for CAR screening in primary T cells using fitness-guided design and mRNA electroporationOkuma, A.; Ishida, Y.; Hisada, S.CD19CD19-positive haematological cancer10.64898/2026.07.28.7412071Moderate
Jul 30, 2026Endogenous single-cell experiments and stochastic modeling reveal control mechanisms of glucocorticoid receptor dynamics and DUSP1 transcriptionRon, E.; Popinga, A.; Forman, J.; Aguilera, L.; Forero, L.; Munsky, B.NR3C1Glucocorticoid-responsive inflammation10.64898/2026.07.01.7358841Moderate
Jul 29, 2026Safety profiling of CAR-T cells using an organotypic human tissue platformMachado, A.; Birsen, G.; Rajnpreht, I.; Furtado Peter, I.; Colell, S.; Marzal, B.; Fredon, M.; Ziegler-Martin, K.; Martinez Bedoya, D.; Fumagalli, M.; Vimeux, L.; Davanture, S.; Melchiore, F.; Thomas, A.; Collet, M.; Fremand, X.; Burroni, B.; Laugel, B.; Lupo-Mansuet, A.; Prieto, M.; Damotte, D.; Le Doussal, J.-M.; Luu, M.; Dutoit, V.; Garnache-Ottou, F.; Guedan, S.; Migliorini, D.; Donnadieu, E.ERBB2HER2-expressing advanced solid tumours (on-target off-tumour toxicity in healthy lung tissue)10.64898/2026.07.25.7405272Moderate
Jul 29, 2026Gelsolin Counteracts ER Stress-Driven Inflammatory Circuits in Psoriasis-like DermatitisOri, D.; Okude, H.; Konishi, R.; Murase, M.; Hiroki, S.; Takahara, S.; Tanaka, T.; Toyodome, R.; Kano, N.; Kawasaki, T.; Ishii, K.; Kobiyama, K.; Nakashima, H.; Nakashima, K.; Sasai, M.; Yamamoto, M.; Kumagai, Y.; Tsuru, A.; Kohno, K.; Kawai, T.TLR9Psoriasis-like dermatitis10.1101/2025.11.20.6894132Moderate
Jul 29, 2026Network Pharmacology-Guided Discovery of Fungal Autophagy Modulators for Tauopathies: Structural and Proteomic EvidenceTorres Mc Cook, A. R.; Mimura, C. B.; Alvarez, L. D.; Liberman, A. C.GSK3BTauopathies10.64898/2026.07.24.7403671Mild
Jul 28, 2026Circulating colorectal tumor cells remodel their surfaceome to increase their viability and metastatic potential in the bloodstreamCabaud, O.; Aulas, A.; Lopresti, A. M.; Acquaviva, C.; Finetti, P.; Dessaux, C.; Ganier, L.; Da-Costa, Q.; Germier, C.; Mescam, L.; Elkaoutari, A.; Audebert, S.; Camoin, L.; de Rauglaudre, B.; Boudin, L.; Denicolai, E.; Lumet, G.; Cohendet, A.; Picard, M.; Birnbaum, D.; Gouarne, C.; Chanez, B.; De Chaisemartin, C.; Lelong, B.; Marchetto, S.; Goncalves, A.; Bertucci, F.; Borg, J.-P.; Mamessier, E.PTK7Colorectal cancer metastasis10.64898/2026.07.24.7405261Mild
Jul 28, 2026AKT1/mTOR/RICTOR risk variants in Indian hypertrophic cardiomyopathy patientsChittora, H.; Notani, D.; Dhandapany, P. S.MTORHypertrophic cardiomyopathy10.64898/2026.07.23.263587821Moderate
Jul 28, 2026A thalamostriatal brake counteracts cortical recruitment of striatal ensembles in levodopa-induced dyskinesiaWang, J.; Tu, X.-Y.; Liang, J.-X.; Sun, J.-Y.; Xu, W.; Wang, Y.; Yi, X.; Wu, Y.-J.; Li, X.-N.; Liu, Y.-X.; Liu, Z.; Li, W.-G.; Song, L.GRIN1Levodopa-induced dyskinesia10.64898/2026.07.22.7402231Moderate
Jul 28, 2026Desialylated platelets promote hepatocyte proliferation via the ERK1/2 signaling pathwayNoboruo, I.; Nakamura, T.; Okumura, M.; Nishijima, T.; Inada, H.; Tanaka, Y.; Kawaguchi, T.; Matsuoka, M.; Yasunaga, J.-i.; Uchiba, M.; Kozuma, Y.MAPK1Liver regeneration and hepatocyte proliferation10.64898/2026.07.26.7402931Moderate
Jul 28, 2026Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed ImmunotherapyGottumukkala, N. V.; Loja, T.; Smida, M.CD19B cell malignancies treated with CD19-directed immunotherapy10.64898/2026.07.26.7407511Moderate
Jul 28, 2026Beyond Immune Evasion: CD47-Driven Pro-Tumorigenic Dysfunction in Diffuse Large B Cell Lymphoma and Triple-Negative Breast CancerLum, T. C. I.; Tan, J. Y. M.; Ng, F. J. H.; Leong, S. M.; Bin Masroni, M. S.; Hue, S. S. S.CD47Diffuse large B cell lymphoma and triple-negative breast cancer10.64898/2026.07.25.7406522Moderate
Jul 28, 2026Neuropilin-1 functions as a proviral and immunoregulatory host factor during Chikungunya virus infectionTung, K. S.; Mahish, C.; Ghosh, S.; Mukherjee, K.; Singh, S.; Bhowmick, B.; Khamaru, S.; Borasi, H.; Gaur, M.; Subudhi, B. B.; Chattopadhyay, S.; Chattopadhyay, S.NRP1Chikungunya virus infection10.64898/2026.07.27.7410041Mild
Jul 27, 2026IL-13 Induces a Tuft Cell-Intrinsic CD45 Checkpoint to Limit Intestinal Type 2 ImmunitySochen, C.; Lebon, S.; Habshush-Menachem, A.; Sarusi-Portuguez, A.; Holiar, V.; Rudenko, V.; Toval, B.; Liu, J.; Levin, Y.; Vaaknin, E.; Rosenthal, N.; Tiferet, N.; Orr, I.; Ben-Dor, S.; Haffner-Krausz, R.; Grencis, R.; Munitz, A.; Karo-Atar, D.; Shulman, Z.; Biton, M.IL13Intestinal type 2 immunity10.64898/2026.07.24.7403761Moderate
Jul 27, 2026IL-23 Licenses Pathogenic Th17 Transdifferentiation via STAT4-dependent Upregulation of IL-12Rβ2Chadha, A. S.; Elahi, A.; Frey, B. F.; Nagaoka-Kamata, Y.; Zindl, C. L.; Schoeb, T. R.; Glassman, C. R.; Garcia, K. C.; Weaver, C. T.IL23AChronic autoimmune intestinal inflammation10.64898/2026.07.23.7403202Moderate
Jul 27, 2026Dual stimulation of CD40 and 41BB pathways during ex-vivo TIL expansion enhances CD8+ T cell expansionMarques Rossetti, R. A.; S. Beatty, M.; Cianne, J.; R. Ali, J.; Harris, K.; Ramadan, A.; Grant, M.; Martinez Planes, E.; Aurelio, J.; Karapetyan, L.; Creelan, B.; Pilon-Thomas, S.; Hwu, P.; Luca, V. C.; Abate-Daga, D.CD40Melanoma and lung cancer, tumor-infiltrating lymphocyte therapy10.64898/2026.07.22.7401283Strong
Jul 26, 2026Occurrence of Biased mTOR Signaling in Hepatocellular CarcinomaSingh, R.; Patel, N.; Singh, N.; Mourya, P.; Shingade, A.; Mange, A.; Kaur, J.; Beloshe, S.; Dudhalkar, A.; Chavan, P.; Yengkhom, G. D.; Patkar, S.; Goel, M.; Ingle, A.; Tripathy, S. R.; Epari, S.; Arandkar, S.; Thorat, R.; Shetty, S.MTORHepatocellular carcinoma10.64898/2026.05.22.7271881Moderate
Jul 26, 2026SynNotch receptors for visualizing immunoreceptor force transmission and downstream signaling in vivoLi, M.; Lyu, J.; Li, K.; Dravid, A.; Balasubramani, D.; Kazemipour Ashkezari, A. H.; Choi, H.-K.; Kwong, G. A.; Singh, A.; Zhu, C.CD40Solid tumor immune activation (CD40 and T cell receptor mechanosignaling)10.64898/2026.06.26.7345581Moderate
Jul 26, 2026Unveiling Gloriosine as a Dual-Acting Regulator of Glutamine Metabolism and Ferroptosis in Triple-Negative Breast Cancer: Insights from Network Pharmacology and Experimental ValidationDey, B.; Chatterjee, E.; Goel, B.; Jain, S. K.; Naik, P. K.; Guru, S. K.MTORTriple-negative breast cancer10.64898/2026.05.17.7253211Moderate
Jul 11, 2026Argininosuccinate Synthase 1 links hepatic urea cycle to whole body lipid metabolismKim, L. C.; Lesner, N. P.; Cai, X.; Han, X.; Jung, J. W.; Xu, J. P.; Coffey, N. J.; Zheng, D.; Brown, M. L.; Mesaros, C.; Arany, Z.; Simon, M. C.ASS1Hepatocellular carcinoma10.64898/2026.06.02.7296181Moderate
Jul 8, 2026CD47 blockade augments anti-GD2 driven phagocytosis in vitro but fails to improve in vivo efficacy in immune competent, chemoresistant neuroblastoma preclinical modelsHimsworth, C.; Jackson, T.; Bowers, C.; Munnings-Tomes, S.; Nair, G.; Muller, H.; Tucker, E.; Erbe-Gurel, A. K.; Sondel, P.; Chesler, L.; Mazjner, R.; Anderson, J.CD47Neuroblastoma10.64898/2026.07.02.7360041Mild
Jul 6, 2026Peptide allosteric inhibitor of TNFR1 signaling attenuates inflammation and rheumatoid arthritis pathology in human TNF transgenic miceRiyed, T. H.; Kalary, K.; Zeng, J.; Lo, C. H.TNFRheumatoid arthritis10.64898/2026.06.30.7357041Moderate
Jul 6, 2026Kappa opioid receptors (KORs) in the anterior paraventricular nucleus of the thalamus (aPVT) mediate morphine withdrawal-, anxiety-, fear-, and KOR agonist-induced aversion-like behaviors in miceHuang, P.; Chen, C.; Bland, K.; Anand, A.; Beier, K.; Liu-Chen, L.-Y.OPRK1Kappa opioid receptor circuit in aversion and mood behaviors10.64898/2026.06.30.7356251Moderate
Jun 26, 2026Bispecific Antibody Architecture and TNFRSF Target Selection Determine CD8+ T Cell Differentiation and Anti-tumour ImmunityWiddess MA, Wilkinson L, Metcalfe HJ, Pakidi A, Chan HC, Kim J, Inzhelevskaya T, Turaj A, Lim SH, Thirdborough SM, Beers SA, Cragg MS, Al-Shamkhani ATNFRSF9Solid tumours (B7-H3-positive; CD8+ T cell co-stimulation)10.64898/2026.06.19.7326422Moderate
Jun 24, 2026AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid PathologyAbdel-Rahman, S.; Gabr, M.LILRB4Alzheimer's disease10.64898/2026.06.12.7318451Mild
Jun 24, 2026From DNA-Encoded Library (DEL) Screening to In Vivo Validation: LILRB4 (ILT3)-Targeted Small Molecules Reprograms Myeloid Immune SuppressionAbdel-Rahman, S.; Gabr, M.LILRB4Alzheimer's disease10.64898/2026.06.10.7312671Mild
Jun 20, 2026CRISPR/Cas9-based knockout screening revealed GSK3beta as a key regulator for structural plasticity of axon initial segmentDu, Y.; Egawa, R.; Adachi, R.; Motohara, K.; Furumichi, K.; Fukaya, R.; Kuba, H.GSK3B—10.64898/2026.05.21.7267871Mild
Jun 20, 2026Region-specific regulation of glucocorticoid and mineralocorticoid receptor signaling in a mouse model of oral contraceptive exposureSchuh, K. M.; Woock, M. G.; Vaandrager, M. J.; Romano, E. G.; He, Y.; Ludmir, D.; Tronson, N. C.NR3C1—10.64898/2026.06.15.7319331Moderate
Jun 17, 2026GPCR-mediated regulation of glial TNF productionStellwagen, D.; Abbasi, Z.; Sadighparvar, S.; Franquin, M.TNFGlial neuroinflammation (TNF regulation)10.64898/2026.06.12.7318541Moderate
Jun 17, 2026Effects of oxidative stress and aging on nerve, muscle, and synapse in a male-specific abdominal neuromuscular junction in DrosophilaUeda, A.; Wu, C.-F.SOD1Amyotrophic lateral sclerosis (SOD1 oxidative-stress model)10.64898/2026.06.10.7314801Moderate
Jun 15, 2026Systematic AI-Driven Drug Repurposing via Clinical Trial Data Mining: A Framework and Six Cross-Therapeutic Case Studies.Gote, V.TNFEarly-stage neurodegeneration (repurposing hypothesis)10.64898/2026.06.11.7316291Moderate
Jun 12, 2026Mutant SOD1 expressed by oligodendrocytes aggregates in myelinic nanochannels and accelerates disease progression in familial ALS miceMot, A. I.; Li, Y.; Dibaj, P.; Tzvetanova, I. D.; Gerwig, U. C.; Bogale, T. A.; Goebbels, S.; Möbius, W.; Bergles, D. E.; Morrison, B. M.; Rothstein, J. D.; Cleveland, D. W.; Edgar, J. M.; Nave, K.-A.SOD1Amyotrophic lateral sclerosis (familial, SOD1-mutant)10.64898/2026.06.09.7311001Moderate
Jun 11, 2026Profilin-1 Deficiency Activates STING to Drive T Cell-Mediated Anti-Tumor Immunity in Breast CancerEder, I.; Baghaei, M.; Maurya, S.; Yu, V.; Wilson, E.; Kashkoush, A.; Liu, J.-J.; Liu, S.; Luo, J.; Storkus, W.; Roy, P.STING1Breast cancer10.64898/2026.06.05.7303621Mild
Jun 11, 2026Receptor-structured modelling of EGFR-driven tumor initiation: from spatially resolved cell-based simulations to reduced population dynamicsQasim, R.; BOUCHNITA, A.EGFREGFR-driven tumor initiation (solid tumor)10.64898/2026.06.05.7305291Mild
Jun 9, 2026Spinal Cord Injury Imprints a Glucocorticoid-Driven Failure State in Hematopoietic Stem CellsRodgers, K. A.; Garfinkle, E. A.; Kigerl, K. A.; Asghari, E.; Mifflin, K. A.; Hall, J.; Kulkarni, R.; Wang, C.; Goda, C.; Rodrigues Dias, A. C.; Guan, Z.; Karunasiri, M.; Ma, Q.; Miller, K. E.; Dorrance, A.; Popovich, P. G.NR3C1Spinal cord injury (hematopoietic stem cell failure)10.1101/2025.10.05.6805351Moderate
Jun 7, 2026Beta-Adrenergic Stimulation and MYH7 G256E Mutant Gene Dosage Drive Hypertrophic Cardiomyopathy Phenotype PenetranceHeinrich, P.; Jung, R. M.; Achter, J. S.; Nguyen, V. X.; Lee, C. A.; Sailer, C.; Domian, H.; Vander Roest, A. S.; Suchy, F. P.; Jahng, J. W.; Kojic, A.; Lee, D.; Paasche, A.; Roberts, B.; Nakauchi, H.; Zhu, H.; Wu, J. C.; Bernstein, D.; Moretti, A.; Lundby, A.; Lee, S.; Wu, S. M.MYH7Hypertrophic cardiomyopathy10.64898/2026.06.02.7294111Mild
Jun 7, 2026Uncovering moonlighting role of mitochondrial presequence translocase machinery in SOD1-mediated ALS pathogenesisWaingankar, T. P.; Paliwal, A.; Deep, A.; D'Silva, P.SOD1Amyotrophic lateral sclerosis (SOD1)10.64898/2026.06.03.7297911Moderate
Jun 6, 2026EGFR Inhibition Promotes Enteroendocrine Cell Differentiation Contributing To Treatment-Associated DiarrheaRamos, G. P.; Zeve, D.; Shepherd, A.; Saint-Denis, E.; Aldefer, O.; Frintu, B.; Dale, S.; Sharma, K.; Mohlmann, E.; Mannam, P.; Byers, M.; Terzian, J.; Ribeiro, C. D.; Silva Oliveira, L. F.; Borges, K. S.; O'Connell, A. E.; Carlone, D.; Florez, N.; Rao, M. E.; Breault, D. P.EGFRTreatment-associated diarrhea (EGFR inhibition)10.64898/2026.06.02.7296501Mild
Jun 5, 2026Spatially confined niches support hypoxia-associated transcriptional plasticity contributing to malignant progression in IDH-mutant gliomasDas, D.; Pandele, A.; Jariwala, V. D.; Ghariwala, N. S.; Mohammed, A. O.; Das, T.; Krolla, C.; Arosh, S. M.; Hossain, N.; Shhab, M. A.; Hosen, I.; Smith, S. J.; Grauvogel, J.; Vasilikos, I.; Roelz, R.; Nakgawa, J.; Hoefllin, R.; Tirosh, I.; Juratli, T.; Schneider, M.; Prinz, M.; Hervey-Jumper, S.; Rahman, R.; Boerries, M.; Beck, J.; Jospeh, K.; Andrieux, G.; Ravi, V. M.; Chakraborty, S.EGFRIDH-mutant glioma10.64898/2026.05.31.7291051Mild
Jun 3, 2026CD96-mediated internalisation of ligand CD155 as a novel mechanism for immune regulationShinko, D.; Ford, R. A.; Kos, M.; Attrill, M. H.; Wu, R.; Spector, R.; Pesenacker, A. M.TIGITSolid tumor immune regulation (CD155 / TIGIT axis)10.64898/2026.05.29.7278531Moderate
Jun 3, 2026Long-read Oxford Nanopore sequencing reveals complex rearrangements and regulatory disruption in malignant pleural mesotheliomaAlhazmi, M. H.; Poile, C.; Dzialo, J.; Bzura, A.; Kutywayo, K.; Fennell, D.; Hollox, E. J.WEE1Malignant pleural mesothelioma10.64898/2026.05.26.263538641Mild
Jun 2, 2026AXL-GAS6/PROS1 Interaction: A Critical Switch Between Aberrant- and Healthy Repair Following Alveolar Lung InjurySoetopo D, Mayr CH, Fundel-Clemens K, Ramirez F, Viollet C, Dick A, Rust W, Santacruz D, Hoevels Y, Applebee CJ, Legg S, Funk A, Schnapp G, Padget J, Strobel B, Thomas MJ, Ward SG, Larijani B, Geillinger-Kaestle KAXLIdiopathic pulmonary fibrosis10.1101/2025.04.07.6475671Mild
May 25, 2026Reactivation of DRP1 plays a functional role in resistance to MEK inhibition in pancreatic cancer cellsSharmin, S.; Kashatus, J. A.; Adair, S. J.; Bakall Loewgren, E.; Fallahi-Sichani, M.; Bauer, T. W.; Kashatus, D.CDK6Pancreatic ductal adenocarcinoma (PDAC), KRAS-driven10.64898/2026.05.20.7266632Moderate
May 24, 2026Time-Resolved Phosphoproteomics-Guided BFS Beam Search Reveals Cell-Type-Specific EGFR Signaling Architectures and SHP2 Inhibitor-Induced Pathway RewiringLee, H.; Lee, G.EGFRSolid tumors with EGFR-driven signaling10.64898/2026.03.20.7127751Mild
May 24, 2026Lapatinib Suppressed the Expression of Proinflammatory Cytokines and Alleviated Pain Behavior in a Mouse Model of Postoperative PainKyomuhangi, A.TNFPostoperative inflammatory pain (model)10.64898/2026.01.07.6982121Moderate
May 22, 2026TKI-Tolerant Persisters Emerge from a PKCα-Dependent and Highly Plastic Subpopulation of Stem-Like Cells in NSCLCSadeghi, M.; Salama, M.; Choudhury, S.; Huang, A.; Yang, J.; Hannun, Y. A.EGFREGFR-mutant non-small cell lung carcinoma10.64898/2026.05.20.7264971Mild
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