A comprehensive temporal proteome and phosphoproteome dataset of Y1 adrenocortical cells under FGF2 stimulation and SOS inhibition

This preprint contributes a temporal proteome and phosphoproteome resource in Y1 mouse adrenocortical cells, built on the claim that KRAS amplification and SOS-mediated activation sustain elevated ERK output and that SOS is not solely responsible for KRAS activation in that system. The Claidex graph holds two KRAS failures. bgb-53038-kras-solid-tumors-phase1-strategic-reprioritization closed a Phase 1 program citing lack of promising efficacy alongside internal prioritization. sotorasib-durvalumab-kras-g12c-ctdna-stage3-nsclc-phase2-enrollment-collapse closed for lack of enrollment in a ctDNA-selected stage III population. Neither failure bears on the biochemistry reported here, and this work is a mouse cell-line dataset rather than a therapeutic hypothesis. The flag records target overlap at the severity the rules assign and should be read as a pointer to the GEF and GAP layer the preprint identifies as unresolved, not as a contradiction of either trial.